Levamlodipine is a calcium channel blocker used to treat hypertension. Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of amlodipine, an antihypertensive medication.
- Mechanism
- Curator reviewed · 4 references
Levamlodipine blocks the transmembrane influx of calcium through L-type calcium channels into the vascular and cardiac smooth muscles resulting in vasodilation and a subsequent decrease in blood pressure. Levamlodipine inhibits calcium influx in vascular smooth muscle to a greater degree than in cardiac muscle, leading to decreased peripheral vascular resistance and lowered blood pressure. In vitro studies have shown a negative inotropic effect but this is unlikely to be clinically relevant.
- Primary indication
- Levamlodipine is indicated alone or in combination to treat hypertension in adults and children.Curator reviewed · 2 structured indications
- Formula / weight
- C20H25ClN2O5 · 408.88 g/mol (avg)
- First approval
- United States, 2020
- Also known as
- Levoamlodipine · S-amlodipine
- Brand names
Resolves to
HTIQEAQVCYTUBX-KRWDZBQOSA-NSMILESCCOC(=O)C1=C(COCCN)NC(C)=C([C@@H]1C1=CC=CC=C1Cl)C(=O)OCWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Levamlodipine, and which of those have an active Phase 3 trial?
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