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Displaying results 2121 - 2130 of 10000 in total
  1. Drug

    Ruxolitinib

    go.drugbank.com/drugs/DB08877
    ApprovedInvestigational

    severe complications [L31968] thus the drug was not approved as a treatment for COVID-19. … It is a potent and selective inhibitor of JAK1 and JAK2,[A229698] which are tyrosine kinases involved in cytokine signalling and hematopoiesis.

    Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic IndexProducts: JAKAVİ 10 MG TABLET, 56 ADET, JAKAVI 5 MG TABLET, 14 ADET
  2. Drug

    Methylphenidate

    go.drugbank.com/drugs/DB00422
    ApprovedInvestigational

    Concerta also provides a sustained 10-12 hour effect, allowing for once-daily dosing. … The MLRTM release system allows for a sustained effect for 10-12 hours, allowing for once-daily dosing that covers the major times that ADHD impairment might occur (such as school, homework periods, during

    Mixtures: MEDIKINET MR, MEDIKINET MRCategories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 3-Ring
  3. Drug

    Nebivolol

    go.drugbank.com/drugs/DB04861
    ApprovedInvestigational

    [A182594] Nebivolol was granted FDA approval on 17 December 2007.[L7985] … Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity.

    Mixtures: AMLONEB 10 MG/5 MG TABLET, 30 ADET, AMLONEB 10 MG/5 MG TABLET, 90 ADETCategories: Adrenergic beta-1 Receptor Agonists, Heterocyclic Compounds, 1-Ring
  4. Drug

    Simethicone

    go.drugbank.com/drugs/DB09512
    ApprovedInvestigational

    [A228308] It has a favourable safety profile as it is not systemically absorbed.[A228308] Simethicone has been in use since the 1940s[A228303] but was granted FDA approval in 1952.[A228308] … Simethicone is a silicon based surfactant that decreases the surface tension of gastrointestinal gas bubbles to facilitate their elimination.

    Mixtures: LIBERTRIM® SII 100 MG, BROMUX D® 100/300 MG CÁPSULA.Categories: Compounds used in a research, industrial, or household setting
  5. Drug

    Fluoxetine

    go.drugbank.com/drugs/DB00472
    ApprovedInvestigationalVet approved

    Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). … [A181673] It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies

    Mixtures: Sentraflox AM-10, TARGET 12 MG /50 MG KAPSUL, 30 ADETCategories: Serotonin 5-HT2 Receptor Antagonists, Serotonin 5-HT2C Receptor Antagonists
  6. Drug

    Metoprolol

    go.drugbank.com/drugs/DB00264
    ApprovedInvestigational

    Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release. … [T274] To this date, it is one of the preferred beta-blockers in general clinical guidelines and it is widely prescribed in the Netherlands, New Zealand, and the US.

    Mixtures: Implicor 50 mg/5 mg Filmtabletten, IMPLICOR FILM-COATED TABLET 50 mg/5 mgCategories: Adrenergic beta-1 Receptor Antagonists, Cytochrome P-450 Substrates
  7. Drug

    Lisinopril

    go.drugbank.com/drugs/DB00722
    ApprovedInvestigational

    [A184853] It functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin aldosterone system. … [A184781,A184808,A184817] ACEIs are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta blockers.

    Mixtures: LISAM 10 mg/5 mg Tabletten, AMLIPIN 5 / 10 MG FILM TABLET, 30 ADETCategories: Compounds used in a research, industrial, or household setting
  8. Drug

    Baclofen

    go.drugbank.com/drugs/DB00181
    ApprovedInvestigational

    Baclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant. … [A245338] Baclofen was reintroduced in 1971 as a treatment for spasticity and was later approved by the FDA in 1977.

    Mixtures: Innoprax-5Categories: GABA-B Receptor Agonists
  9. Drug

    Crovalimab

    go.drugbank.com/drugs/DB16128
    ApprovedInvestigational

    Crovalimab is a humanized monoclonal antibody and complement C5 inhibitor.[L50908] It consists of two heavy chains (451 amino acid residues each) and two light chains (217 amino acid residues each). … [A263958] It soon gained its approval in Japan in the next month,[A263958] and in the USA in June of the same year.

    Categories: Complement C5 inhibitorsSynonyms: Complement c5 inhibitory humanized recycling monoclonal antibody (rg-6107 ), IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENS C5 (COMPLEMENT 5)), MONOCLONAL ANTIBODYGAMMA1 HEAVY CHAIN (1-451) (VH (VICUGNA PACOS IGHV3S1*01 (70.4%)/HOMO SAPIENS IGHV3-66*01 (69.4%)-(IGHD)-HOMO SAPIENS
  10. Drug

    Protamine sulfate

    go.drugbank.com/drugs/DB09141
    ApprovedInvestigational

    recovery of a patient after the procedure [A174778, A174781, L5371]. … Since it's earliest discovery in salmon rine sperm heads in the late 1800's to its formal introduction via US FDA approval in 1939, protamine sulfate has occupied an important therapeutic niche as perhaps

    Products: PAMINTU 10 MG/ML ENJEKSIYONLUK ÇÖZELTI IÇEREN FLAKON 5 ML, 10 ADET, PAMINTU 10 MG/ML ENJEKSIYONLUK ÇÖZELTI IÇEREN FLAKON 5 ML, 15 ADET