Metoprolol is a beta-blocker used in the treatment of hypertension and angina, and used to reduce mortality due to myocardial infarction. Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.
- Mechanism
- Curator reviewed · 1 reference
Metoprolol is a beta-1-adrenergic receptor inhibitor specific to cardiac cells with negligible effect on beta-2 receptors. This inhibition decreases cardiac output by producing negative chronotropic and inotropic effects without presenting activity towards membrane stabilization nor intrinsic sympathomimetics.
- Primary indication
- Metoprolol is indicated for the treatment of angina, heart failure, myocardial infarction, atrial fibrillation, atrial flutter and hypertension.Curator reviewed · 10 structured indications
- Formula / weight
- C15H25NO3 · 267.3639 g/mol (avg)
- First approval
- Canada, 1997 · United States, 1978
- Also known as
- (RS)-Metoprolol · DL-metoprolol
- Code names
- CGP-2175
- Brand names
Resolves to
IUBSYMUCCVWXPE-UHFFFAOYSA-NSMILESCOCCC1=CC=C(OCC(O)CNC(C)C)C=C1What you can answer from here — as of September 21, 2026
Which drugs share a target with Metoprolol, and which of those have an active Phase 3 trial?
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