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Displaying results 2121 - 2130 of 9325 in total
  1. Drug

    Alogliptin

    go.drugbank.com/drugs/DB06203
    ApprovedInvestigational

    Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer.

  2. Drug

    Voclosporin

    go.drugbank.com/drugs/DB11693
    ApprovedInvestigational

    Early intervention with voclosporin coupled with a kidney response is believed to prevent irreversible damage to the kidney and lead to better long-term clinical outcomes for patients with LN. … for the treatment of adult patients with active lupus nephritis.

  3. Drug

    Terconazole

    go.drugbank.com/drugs/DB00251
    Approved

    [A178093]Due to the existence of 2 stereocentres, there are 4 possible stereoisomers for terconazole. … [A178096] Terconazole was initially approved by the FDA in 1987.

    Products: FUNGISTAT OVULOS DE 80 MG., FUNGISTAT CREMA VAGINAL DE 0.8%
  4. Drug

    Nemolizumab

    go.drugbank.com/drugs/DB15252
    ApprovedInvestigational

    [A264254] By binding to IL-31RA, nemolizumab blocks the IL-31 signalling cascades that lead to inflammation. … [A264274] It was later approved by the FDA on August 13, 2024, for the treatment of prurigo nodularis.[L51169]

  5. Drug

    Bacampicillin

    go.drugbank.com/drugs/DB01602
    ApprovedWithdrawn

    During absorption from the gastrointestinal tract, bacampicillin is hydrolyzed by esterases present in the intestinal wall. … It is microbiologically active as ampicillin, and exerts a bactericidal action through the inhibition of the biosynthesis of cell wall mucopeptides.

  6. Drug

    Darolutamide

    go.drugbank.com/drugs/DB12941
    ApprovedInvestigational

    The goal of treatment with darolutamide is to delay the progression of prostate cancer to metastatic disease, increasing quality of life and life expectancy for those with advanced prostate cancer. … [A189063] Though prior treatment for prostate cancer has been successful for these patients, the cancer eventually progresses to become resistant to existing therapies.

  7. Drug

    Dimethyl fumarate

    go.drugbank.com/drugs/DB08908
    ApprovedInvestigational

    in response to oxidative stress. … It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated

    Synonyms: (E)-But-2-enedioic acid dimethyl esterProducts: D-FUMARIC 240 CAPSULAS DE LIBERACIÓN RETARDADA 240 MG, D-FUMARIC 120 CAPSULAS DE LIBERACION RETARDADA 120 MG
  8. Drug

    Troglitazone

    go.drugbank.com/drugs/DB00197
    ApprovedWithdrawn

    Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone].

  9. Drug

    Vayarin

    go.drugbank.com/drugs/DB09328
    Approved

    Cost of the drug and patient aversion to the taste of Vayarin were significant reasons for therapy failure [L1502]. … Vayarin is a specially formulated and designed to address the distinct, previously determined lipid nutritional requirements of children with ADHD, the dietary management of which cannot be achieved with

  10. Drug

    Methylchloroisothiazolinone

    go.drugbank.com/drugs/DB14197
    Approved

    The American Contact Dermatitis Society named Methylchloroisothiazolinone the Contact Allergen of the Year for 2013. … Sensitivity to Methylchloroisothiazolinone may be identified with a clinical patch test.