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Daclatasvir
go.drugbank.com/drugs/DB09102ApprovedInvestigationalWithdrawnIt exerts its antiviral action by preventing RNA replication and virion assembly via binding to NS5A, a nonstructural phosphoprotein encoded by HCV.
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesPerospirone
go.drugbank.com/drugs/DB08922InvestigationalPerospirone is an atypical or second-generation antipsychotic of the azapirone family that antagonizes serotonin 5HT2A receptors and dopamine D2 receptors. It also displays affinity towards 5HT1A receptors as a partial agonist. Dainippon...
Categories: Dopamine D2 Receptor Antagonists, Cytochrome P-450 SubstratesImidafenacin
go.drugbank.com/drugs/DB09262InvestigationalImidafenacin is an antispasmodic agent with anticholinergic effects. It antagonizes muscarinic receptors in the bladder to reduce the frequency of urination in the treatment of overactive bladder. It is marketed in Japan under the traden...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesNeutral amino acid transporter B(0)
go.drugbank.com/bio_entities/BE0000236TargetTransporterHumansMediates D-serine release from the retinal glia potentially affecting NMDA receptor function in retinal neurons.
Synonyms: Baboon M7 virus receptor, RD114/simian type D retrovirus receptorAcetic acid
go.drugbank.com/drugs/DB03166ApprovedInvestigationalAcetic acid is a product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed) Acetic acid otic (for the ear) ...
Mixtures: Fem pH, Acetate Buffer Ph 4.85CD320 antigen
go.drugbank.com/bio_entities/BE0019797TransporterHumansReceptor for transcobalamin saturated with cobalamin (TCbl) (PubMed:18779389). Plays an important role in cobalamin uptake (PubMed:18779389, PubMed:20524213).
Synonyms: Transcobalamin receptorVolume-regulated anion channel subunit LRRC8A
go.drugbank.com/bio_entities/BE0016599TargetHumansEssential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24725410, PubM...
Synonyms: Leucine-rich repeat-containing protein 8ASteroidogenic factor 1
go.drugbank.com/bio_entities/BE0003359TargetHumansTranscriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues (PubMed:27378692). Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B a...
Synonyms: Steroid hormone receptor Ad4BP, Nuclear receptor subfamily 5 group A member 1Janus (JAK) kinases
go.drugbank.com/bio_entities/BE0027976TargetHumansIn the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. … The heterodimeric cytokine receptor complexes are composed of (1) a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1), and (2) a second receptor chain associated either with JAK1 or JAK2
Polypeptides: Non-receptor tyrosine-protein kinase TYK2Function: acetylcholine receptor bindingLecithin, soybean
go.drugbank.com/drugs/DB14161InvestigationalA complex mixture of phospholipids; glycolipids; and triglycerides; with substantial amounts of phosphatidylcholines; phosphatidylethanolamines; and phosphatidylinositols, which are sometimes loosely termed as 1,2-diacyl-3-phosphocholine...
Mixtures: GNC PP AA Formula