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Bremelanotide
go.drugbank.com/drugs/DB11653Approved[A179686] The mechanism by which bremelanotide's action on receptors translates to a clinical effect is still unknown. … [L9635] Bremelanotide was first described in the literature in 2003 when it was known by the investigational code PT-141.
Categories: Melanocortin Receptor Agonists, Receptor, Melanocortin, Type 3, agonistsTazobactam
go.drugbank.com/drugs/DB01606ApprovedInvestigationalTazobactam is an antibiotic of the beta-lactamase inhibitor class that prevents the breakdown of other antibiotics by beta-lactamase enzyme producing organisms. … Piperacillin-tazobactam was initially approved by the FDA in 1994, and ceftolozane-tazobactam was approved by the FDA in 2014[FDA label], providing wider antibacterial coverage for gram-negative infections
Mixtures: PIPERACILLINA E TAZOBACTAM KABI, PIPERACILLINA E TAZOBACTAM KABIBimekizumab
go.drugbank.com/drugs/DB12917ApprovedInvestigational[L39665,L39680] It is the first IL-17 inhibitor to target both IL-17A and IL-17F. … of moderate-to-severe psoriasis,[A244450,A244455] likely owing to its dual inhibition of both IL-17A and IL-17F.
Ertapenem
go.drugbank.com/drugs/DB00303ApprovedInvestigational[A447] Shown to be effective against a wide range of Gram-positive and Gram-negative aerobic and anaerobic bacteria, ertapenem is used to treat various bacterial infections. … Ertapenem is a 1-β methyl-carbapenem that is structurally related to beta-lactam antibiotics.[L14339] It was first authorized for use in the US in November 2001 and in Europe in April 2002.
Pipradrol
go.drugbank.com/drugs/DB11584ApprovedWithdrawnThe social and in particular acute clinical harms of pipradrol derivatives have led to their control under the Misuse of Drugs Act 1971 in the UK in 2012 [T178]. … Experimentation with the drug and its derivatives for recreational purposes has led to many cases of acute toxicity and has been linked to three fatalities.
Diflunisal
go.drugbank.com/drugs/DB00861ApprovedThough its mechanism of action has not been clearly established, most of its actions appear to be associated with inhibition of prostaglandin synthesis via the arachidonic acid pathway. … Diflunisal is used to relieve pain accompanied with inflammation and in the symptomatic treatment of rheumatoid arthritis and osteoarthritis.
Carbamazepine
go.drugbank.com/drugs/DB00564ApprovedInvestigationalIt was initially approved by the FDA in 1965.[A180301] Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. … [L1335] Interestingly, carbamazepine was the first anticonvulsant used to treat individuals with bipolar disorder.[A180319]
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeProducts: CARBAZOL DE 200 MG, TEGRETOL RETARD DE 200 MGPravastatin
go.drugbank.com/drugs/DB00175ApprovedInvestigationalThe manufacturing process is followed by the hydrolysis of the lactone group and the biological hydroxylation with _Streptomyces carbophilus_ to introduce the allylic 6-alcohol group.[T239] … Pravastatin is the 6-alpha-hydroxy acid form of [mevastatin].[T303] Pravastatin was firstly approved in 1991 becoming the second available statin in the United States.
Products: DAXON TGlymidine
go.drugbank.com/drugs/DB01382ApprovedGlycodiazine is used with diet to lower blood glucose by increasing the secretion of insulin from pancreas and increasing the sensitivity of peripheral tissues to insulin. … tissues to insulin.
Pegfilgrastim
go.drugbank.com/drugs/DB00019ApprovedInvestigationalactivity to filgrastim and binds to the G-CSF receptor to stimulate the proliferation, differentiation, and activation of neutrophils. … [A187631] Due to the relatively short circulating half-life of filgrastim, a 20 kDa PEG moiety was covalently conjugated to the N-terminus of filgrastim (at the methionine residue) to develop longer-acting