Glycodiazine is used with diet to lower blood glucose by increasing the secretion of insulin from pancreas and increasing the sensitivity of peripheral tissues to insulin. The mechanism of action... Glycodiazine likely binds to ATP-sensitive potassium channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane.
- Mechanism
- Curator reviewed
The mechanism of action of glycodiazine in lowering blood glucose appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells, and increasing sensitivity of peripheral tissues to insulin. Glycodiazine likely binds to ATP-sensitive potassium channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Membrane depolarization stimulates calcium ion influx through voltage-sensitive calcium channels. The rise in intracellular calcium leads to increased fusion of insulin granulae with the cell membrane, and therefore increased secretion of (pro)insulin.
- Primary indication
- Glycodiazine is used concomitantly with insulin for the treatment of noninsulin-dependent (type 2) diabetes mellitus.Curator reviewed
- Formula / weight
- C13H15N3O4S · 309.341 g/mol (avg)
- Also known as
- Glidiazine · Glycodiazine
Resolves to
QFWPJPIVLCBXFJ-UHFFFAOYSA-NSMILESCOCCOC1=CN=C(NS(=O)(=O)C2=CC=CC=C2)N=C1What you can answer from here — as of September 13, 2026
Which drugs share a target with Glymidine, and which of those have an active Phase 3 trial?
Create a free account or log in to explore the full data card.
Create Account