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Crisaborole
go.drugbank.com/drugs/DB05219ApprovedInvestigationalIt reduces the local inflammation in the skin and prevents further exacerbation of the disease with a good safety profile. … Its structure contains a boron atom, which facilitates skin penetration and binding to the bimetal center of the phosphodiesterase 4 enzyme.
Lecanemab
go.drugbank.com/drugs/DB14580ApprovedInvestigational[L44537] Lecanemab works to reduce Aβ plaques and prevent Aβ deposition in the brain [A253947,A253952] with high selectivity to Aβ protofibrils. … [A253962,L44547] On January 6, 2023, lecanemab was granted accelerated approval by the FDA for the treatment of Alzheimer’s Disease.[L44547] It was granted full FDA approval on July 6, 2023.
Barium sulfate
go.drugbank.com/drugs/DB11150ApprovedBarium sulfate is an inorganic compound with the chemical formula BaSO4 [L1957]. Barium sulfate occurs in nature as the mineral _barite_. … Barium sulfate is ingested by mouth or administered rectally and combined with granules of effervescent bicarbonate to enhance distension of the GI tract, allowing for enhanced gastrointestinal tract visualization
Mixtures: E-Z HD SULFATODE BARIO PARA SUSPENSION, E-Z HD SULFATODE BARIO PARA SUSPENSIONProducts: E-Z-HD, E-Z PAQUE SULFATO DE BARIO PARA SUSPENSIONDexmethylphenidate
go.drugbank.com/drugs/DB06701ApprovedInvestigationalThe d-isomer is thought to have greater effect with fewer side effects than the l-isomer or the racemic mixture[A177181]. … Dexmethylphenidate is the dextrorotary form of methylphenidate introduced in 2002[A177181]. It is a norepinephrine-dopamine reuptake inhibitor (NDRI) and thus a psychostimulant[A177193].
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeRoxithromycin
go.drugbank.com/drugs/DB00778ApprovedInvestigationalWithdrawnIt was shown to be more effective against certain Gram-negative bacteria, particularly _Legionella pneumophila_. … Roxithromycin exerts its antibacterial action by binding to the bacterial ribosome and interfering with bacterial protein synthesis.
Synonyms: (9E)-erythromycin 9-(O-((2-methoxyethoxy)methyl)oxime)International brands: Heng Te, Bei KeZilucoplan
go.drugbank.com/drugs/DB15636ApprovedInvestigationalIt is a complement inhibitor that works to prevent the activation of C5, which is a complement protein involved in the innate immune system to initiate inflammatory responses. … [L48701] It was also later approved by the EMA on December 4, 2023, as an add-on treatment for the same condition.[L49131] In July 2024, it was approved by Health Canada for the same indication.
Tapinarof
go.drugbank.com/drugs/DB06083ApprovedInvestigationalIt is available as a topical cream to be applied to the affected area once daily. … [A248790] Tapinarof received initial approval from the FDA in 2022.[L41845]
Categories: Aryl Hydrocarbon Receptor AgonistClidinium
go.drugbank.com/drugs/DB00771ApprovedIt is used for the treatment of peptic ulcer disease and also to help relieve abdominal or stomach spasms or cramps due to colicky abdominal pain, diverticulitis, and irritable bowel syndrome. … Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract.
Synonyms: Bromuro de clidinio, Bromure de ClidiniumEtryptamine
go.drugbank.com/drugs/DB01546ApprovedIllicitWithdrawnIn the 1960's, alpha-ethyltryptamine (αET), a non hydrazine reversible monoamine oxidase inhibitor, was developed in the United States by the Upjohn chemical company for use as an antidepressant. αET was … However, in 1962, after the discovery of an unacceptable incidence of agranulocytosis, the development of Monase was halted and the drug was withdrawn from potential market use.
Hydroflumethiazide
go.drugbank.com/drugs/DB00774ApprovedWithdrawnA thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822)