Roxithromycin

DB00778ApprovedInvestigationalWithdrawnSmall molecule

Roxithromycin is an antibiotic used to treat a variety of susceptible bacterial infections. Roxithromycin is a semi-synthethic macrolide antibiotic that is structurally and pharmacologically similar to erythromycin, azithromycin, or clarithromycin.

Mechanism: Roxithromycin prevents bacterial growth by interfering with their protein synthesis. It binds to the 50S subunit of bacterial ribosomes and inhibits the translocation of peptides.
Curator reviewed
Primary indication: Used to treat respiratory tract, urinary and soft tissue infections.Curator reviewed · 4 structured indications
Formula / weight: C₄₁H₇₆N₂O₁₅ · 837.0465 g/mol (avg)
Code names: RU 28965 · RU 965

Resolves to

Compound

UNII21KOF230FACAS80214-83-1ChEMBLCHEMBL1214185ChEBI48935PubChem6915744KEGGD01710

Clinical / RWD

RxNorm9478ATCJ01FA06PharmGKBPA164750505

Structure

InChIKeyRXZBMPWDPOLZGW-XMRMVWPWSA-NSMILES

CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)C(=NOCOCCOC)[C@H](C)[C@@H](O)[C@]1(C)O

Targets

P0A7J6rplJP08183ABCB1

What you can answer from here — as of September 23, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

719Drug interactionsStructured to mechanism, not free text

10Clinical trialsPhase, status and sponsor resolved per trial

4Structured indicationsCondition, population, route and combination as fields, not prose

209Marketed productsAcross 9 countries and 82 labellers

1ATC codeIncluding every combination product, plus 22 drug categories

11+ReferencesStructured and connected to the statements they support

Which drugs share a target with Roxithromycin, and which of those have an active Phase 3 trial?

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