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Sotagliflozin
go.drugbank.com/drugs/DB12713ApprovedInvestigational[L39734] A similar approval has also been sought in the US, but the FDA has since published a proposal to refuse the approval because the data submitted did not show that it was safe under the proposed … Sotagliflozin is a dual inhibitor of SGLT1 and SGLT2, the first of its kind,[A244499] which is approved for use in the EU, in combination with insulin, to improve glycemic control in patients with type
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesUrea C-14
go.drugbank.com/drugs/DB09513ApprovedInvestigationalTo detect H. pylori, urea labeled with 14C is swallowed by the patient. … If gastric urease from H. pylori is present, urea is split to form CO2 and NH3 at the interface between the gastric epithelium and lumen and 14CO2 is absorbed into the blood and exhaled in the breath.
Synonyms: Urea 14 C, Urea C 14Products: HELITEST® CAPSULAS 37 KBQ UREA 14C, PYtest ®(Carbon-14-Urea 1.0 microCurie Breath Test)Cresol
go.drugbank.com/drugs/DB11143ApprovedCresol is a hydroxytoluene that can be extracted naturally from coal tar or made synthetically. Pure cresol is a mixture of ortho-, meta-, and para- isomers. … Ingestion of cresol induces toxicity in humans and can lead to burning of the mouth and throat, abdominal pain, and/or vomiting.
Fenfluramine
go.drugbank.com/drugs/DB00574ApprovedIllicitInvestigationalWithdrawnIt is currently sold under the name FINTEPLA® by Zogenix INC.[L14522] … Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Cytochrome P-450 SubstratesSynonyms: 1-(m-trifluoromethyl-phenyl)-2-ethylaminopropaneFelbamate
go.drugbank.com/drugs/DB00949ApprovedFelbamate is an anticonvulsant drug used in the treatment of epilepsy. In particular, in the adult patient population, it can be employed to treat partial seizures (with and without generalization). … Alternatively, it is used to treat partial and generalized seizures associated with Lennox-Gastaut syndrome in children. It has a weak inhibitory effect on GABA receptor binding sites.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersSynonyms: Carbamic acid 3-carbamoyloxy-2-phenyl-propyl ester, 2-phenyl-1,3-propanediol dicarbamateFostemsavir
go.drugbank.com/drugs/DB11796ApprovedInvestigational[L14867] It binds to and inhibits the activity of gp120, a subunit within the HIV-1 gp160 envelope glycoprotein that facilitates the attachment of HIV-1 to host cell CD4 receptors - in doing so, temsavir … prevents the first step in the HIV-1 viral lifecycle.
Categories: Human Immunodeficiency Virus Type 1 (HIV-1) gp120-directed Attachment Inhibitors, Cytochrome P-450 SubstratesCyclothiazide
go.drugbank.com/drugs/DB00606ApprovedIt is also indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension. … As a diuretic, cyclothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water.
Synonyms: 6-chloro-3-(2-norbornen-5-yl)-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide, 6-chloro-3,4-dihydro-3-(2-norbornen-5-yl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxideCategories: Heterocyclic Compounds, 2-RingEluxadoline
go.drugbank.com/drugs/DB09272ApprovedInvestigationalThe mu-, kappa-, and delta-opioid receptors mediate endogenous and exogenous opioid response in the central nervous system and peripherally in the gastrointestinal system. … Eluxadoline is a mixed mu-opioid receptor agonist, kappa-opioid receptor agonist, and a-delta opioid receptor antagonist indicated for use in diarrhea-predominant irritable bowel syndrome (IBS-D).
Synonyms: 5-({(4-carbamoyl-2,6-dimethyl-L-phenylalanyl)[(1S)-1-(4-phenyl-1H-imidazol-2-yl)ethyl]amino}methyl)-2-methoxybenzoic acidCategories: Heterocyclic Compounds, 1-Ring, Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeTriamterene
go.drugbank.com/drugs/DB00384ApprovedTriamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management of hypertension. … Triamterene is a weak antagonist of folic acid, and a photosensitizing drug.[L6163] Triamterene was approved by the Food and Drug Administration in the U.S. in 1964.
Mixtures: TRIAMETERENO E HIDROCLOROTIAZIDA CAPSULAS, DYTIDE HCategories: Cytochrome P-450 Substrates, Decreased Renal K+ ExcretionChlorthalidone
go.drugbank.com/drugs/DB00310ApprovedInvestigationalIn addition to its antihypertensive effects, chlorthalidone has also been shown to decrease platelet aggregation and vascular permeability, as well as promote angiogenesis in vitro, which is thought to … [A173884, A173887] Further studies have indicated that low-dose thiazides are as good as, and in some secondary endpoints, better than β-blockers, ACE inhibitors, Calcium Channel Blockers or ARBs.
Mixtures: ATENOLOLO E CLORTALIDONE MYLAN GENERICS, ATENOLOLO E CLORTALIDONE MYLAN GENERICSCategories: Heterocyclic Compounds, 2-Ring