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Miltefosine
go.drugbank.com/drugs/DB09031ApprovedInvestigationalIt is currently the only recognized oral agent used to treat visceral, cutaneous, and mucosal forms of leishmaniasis, a neglected tropical disease. … Miltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid drug that was originally developed in the 1980s as an anti-cancer agent.
Categories: P-glycoprotein substratesSynonyms: hexadecyl 2-(trimethylazaniumyl)ethyl phosphateLeucovorin
go.drugbank.com/drugs/DB00650ApprovedInvestigational[L56091, L56092] Additionally, it is used in combination with 5-fluorouracil (5-FU) to enhance therapeutic efficacy in the palliative treatment of advanced colorectal cancer and to treat megaloblastic … [A275451] It is primarily indicated for "leucovorin rescue" to diminish the hematologic and mucosal toxicity of high-dose methotrexate therapy in osteosarcoma and to treat inadvertent overdoses of folic
Synonyms: N-(5-formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid, L(-)-5-Formyl-5,6,7,8-tetrahydrofolic acidCategories: Vitamin B Complex, Heterocyclic Compounds, 2-RingSertindole
go.drugbank.com/drugs/DB06144ApprovedWithdrawnSertindole, a neuroleptic, is one of the newer antipsychotic medications available. Serdolect is developed by the Danish pharmaceutical company H. Lundbeck. … It is a phenylindole derivative used in the treatment of schizophrenia.
Synonyms: 1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1-piperidyl]ethyl]imidazolidin-2-oneCategories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Cytochrome P-450 SubstratesCyclothiazide
go.drugbank.com/drugs/DB00606ApprovedIt is also indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension. … As a diuretic, cyclothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water.
Synonyms: 6-chloro-3-(2-norbornen-5-yl)-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide, 6-chloro-3,4-dihydro-3-(2-norbornen-5-yl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxideCategories: Heterocyclic Compounds, 2-RingTacrolimus
go.drugbank.com/drugs/DB00864ApprovedInvestigationalTacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. … It was discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. Tacrolimus is chemically known as a macrolide.
Mixtures: Hyaluronic Acid Sodium Salt 1% / Niacinamide 4% / Tacrolimus 0.1%, Niacinamide 4% / Tacrolimus 0.1%Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexBerdazimer
go.drugbank.com/drugs/DB18712ApprovedIt is one of the 5 most prevalent skin diseases in the world and the third-most common viral skin infection in children. … [A262965] On Jan 05, 2024, the FDA approved berdazimer under the brand name ZELSUVMI for the treatment of adult and pediatric molluscum contagiosum, and it is the first drug to be approved for this
Synonyms: Silsesquioxanes, 3-(2-hydroxy-1-methyl-2-nitrosohydrazinyl)propyl 3-(methylamino)propyl, polymers with silicic acid (h4sio4) tetra-et ester, hydroxy-terminatedProfenamine
go.drugbank.com/drugs/DB00392ApprovedIt is sold under the trade name Parsitan in Canada.[L46812] In the US, the marketing of profenamine has been discontinued.[L46817] … Profenamine (also known as ethopropazine) is a medication derived from phenothiazine. It is primarily used as an antidyskinetic to treat Parkinsonism.
Categories: Heterocyclic Compounds, 3-RingSynonyms: N,N-diethyl-1-(10H-phenothiazin-10-yl)-2-propanamine, 2-diethylamino-1-propyl-N-dibenzoparathiazineUrea C-14
go.drugbank.com/drugs/DB09513ApprovedInvestigationalTo detect H. pylori, urea labeled with 14C is swallowed by the patient. … If gastric urease from H. pylori is present, urea is split to form CO2 and NH3 at the interface between the gastric epithelium and lumen and 14CO2 is absorbed into the blood and exhaled in the breath.
Synonyms: Urea 14 C, Urea C 14Products: HELITEST® CAPSULAS 37 KBQ UREA 14C, PYtest ®(Carbon-14-Urea 1.0 microCurie Breath Test)Warfarin
go.drugbank.com/drugs/DB00682ApprovedInvestigationalWarfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. … Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America.
Categories: 4-Hydroxycoumarins, Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic IndexSynonyms: 4-Hydroxy-3-(3-oxo-1-phenylbutyl)coumarinBenzgalantamine
go.drugbank.com/drugs/DB19353ApprovedInvestigational[A264454] As a prodrug, benzagalantamine remains inert as it passes through the stomach, thereby avoiding many of the gastrointestinal effects associated with peripheral cholinesterase inhibition. … Benzgalantamine is a prodrug of [galantamine].
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesSynonyms: 6h-benzofuro(3a,3,2-ef)(2)benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, benzoate (ester), (4as,6r,8as)-