Sertindole

DB06144ApprovedWithdrawnSmall molecule

Sertindole is an atypical antipsychotic indicated in the treatment of schizophrenia. Sertindole, a neuroleptic, is one of the newer antipsychotic medications available.

Mechanism: Sertindole is an antipsychotic drug with affinity for dopamine D2, serotonin 5-HT2A and 5-HT2C, and alpha1-adrenoreceptors. Preclinical studies suggest that sertindole acts preferentially on limbic and cortical dopaminergic neurons and clinical trials have confirmed that sertindole is effective at a low dopamine D2 occupancy level.
Curator reviewed
Primary indication: Used in the treatment of schizophrenia.Curator reviewed · 1 structured indication
Formula / weight: C₂₄H₂₆ClFN₄O · 440.941 g/mol (avg)
Code names: LU-23-174

Resolves to

Compound

UNIIGVV4Z879SPCAS106516-24-9ChEMBLCHEMBL12713ChEBI9122PubChem60149KEGGD00561

Clinical / RWD

RxNorm41996ATCN05AE03PharmGKBPA164784002

Structure

InChIKeyGZKLJWGUPQBVJQ-UHFFFAOYSA-NSMILESFC1=CC=C(C=C1)N1C=C(C2CCN(CCN3CCNC3=O)CC2)C2=C1C=CC(Cl)=C2

Targets

P14416DRD2P28223HTR2AP28335HTR2CP50406HTR6Q12809KCNH2P35348ADRA1AP35368ADRA1BP25100ADRA1D

What you can answer from here — as of June 15, 2026

9Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

1,249Drug interactionsStructured to mechanism, not free text

14Clinical trialsPhase, status and sponsor resolved per trial

1Structured indicationCondition, population, route and combination as fields, not prose

25ContraindicationsEach with its own population and attribute set

63Marketed productsAcross 3 countries and 2 labellers

1ATC codeIncluding every combination product, plus 25 drug categories

52+ReferencesStructured and connected to the statements they support

Which drugs share a target with Sertindole, and which of those have an active Phase 3 trial?

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