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Pentamidine
go.drugbank.com/drugs/DB00738ApprovedInvestigationalAntiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other t...
Synonyms: p,p'-(pentamethylenedioxy)dibenzamidineCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A1 SubstratesZileuton
go.drugbank.com/drugs/DB00744ApprovedWithdrawnLeukotrienes are substances that induce numerous biological effects including augmentation of neutrophil and eosinophil migration, neutrophil and monocyte aggregation, leukocyte adhesion, increased capillary permeability, and smooth musc...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsTretinoin
go.drugbank.com/drugs/DB00755ApprovedInvestigationalNutraceuticalTretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is norm...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A1 SubstratesIrinotecan
go.drugbank.com/drugs/DB00762ApprovedInvestigationalIrinotecan is a topoisomerase inhibitor used for chemotherapy. It is a water-soluble analogue of camptothecin, which is extracted from the Chinese tree Camptotheca acuminate. The bis-piperidine side chain in the structure of irinotecan b...
Categories: Cytochrome P-450 CYP2B6 Substrates, Cytochrome P-450 CYP3A InhibitorsMometasone
go.drugbank.com/drugs/DB00764ApprovedInvestigationalMometasone is a corticosteroid not currently used in medical products. Mometasone furoate however, is still in use.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersEtoposide
go.drugbank.com/drugs/DB00773ApprovedInvestigationalA semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair b...
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesBefunolol
go.drugbank.com/drugs/DB09013ExperimentalBefunolol is a beta blocker introduced in 1983 by Kakenyaku Kakko. It is currently in experimental status, and is being tested for the management of open angle glaucoma.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesBrexpiprazole
go.drugbank.com/drugs/DB09128ApprovedInvestigationalBrexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. A...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesDosulepin
go.drugbank.com/drugs/DB09167ApprovedInvestigationalDosulepin (INN, BAN) formerly known as dothiepin (USAN), is a tricyclic antidepressant with anxiolytic properties that is used in several European and South Asian countries, as well as Australia, South Africa, and New Zealand. It is not ...
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP2C9 InhibitorsManidipine
go.drugbank.com/drugs/DB09238ApprovedInvestigationalWithdrawnManidipine (INN) is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive. It is selective for vasculature and does not produce effects on the heart at clinically relevant dosages.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 Inhibitors