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Displaying results 2241 - 2250 of 10000 in total
  1. Drug

    Obecabtagene autoleucel

    go.drugbank.com/drugs/DB17362
    ApprovedInvestigational

    Obecabtagene autoleucel is an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy with a fast off-rate binding profile for CD19. … [A265050] On November 8, 2024, obecabtagene autoleucel was approved by the FDA for the treatment of relapsed or refractory B-cell precursor acute lymphoblastic leukemia.

    Synonyms: A CHIMERIC ANTIGEN RECEPTOR (CAR) CONSISTING O, AUTOLOGOUS CD4+ AND CD8+ T CELLS, ENRICHED FROM PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMCS) OBTAINED BY APHERESIS TRANSDUCED EX VIVO WITH A NON-REPLICATING, SELF-INACTIVATING (SIN) LENTIVIRAL VECTOR, ENCODING
  2. Drug

    Etacrynic acid

    go.drugbank.com/drugs/DB00903
    ApprovedInvestigational

    A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. … This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.

    Categories: Increased Diuresis at Loop of Henle, Medications that reduce magnesium levels
  3. Drug

    Modafinil

    go.drugbank.com/drugs/DB00745
    ApprovedInvestigational

    The exact mechanism of action is unclear, although in vitro studies have shown it to inhibit the reuptake of dopamine by binding to the dopamine reuptake pump, and lead to an increase in extracellular … Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy.

    Categories: Metabolic Side Effects of Drugs and SubstancesProducts: MODIODAL 100 MG TABLET, 30 ADET, CRALİUM 100 MG TABLET, 30 ADET
  4. Drug

    Phthalylsulfathiazole

    go.drugbank.com/drugs/DB13248
    Approved

    Phthalylsulfathiazole is a broad spectrum antibiotic which is part of the drug class, sulfonamides. It was used as an antibiotic for bowel surgery, and for infections of the colon [A175006].

    Categories: combinations of sulfonamides
  5. Drug

    Niraparib

    go.drugbank.com/drugs/DB11793
    ApprovedInvestigational

    Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. … [L43747] On December 12, 2025, the FDA expanded niraparib and abiraterone acetate (AKEEGA) with prednisone for the treatment of patients with BRCA2-mutated metastatic castration-sensitive prostate cancer

    Categories: MATE 1 Substrates with a Narrow Therapeutic Index, MATE 2 Substrates with a Narrow Therapeutic Index
  6. Drug

    Mercaptopurine

    go.drugbank.com/drugs/DB01033
    ApprovedInvestigational

    An antimetabolite antineoplastic agent with immunosuppressant properties. … It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.

    Categories: OAT3/SLC22A8 Substrates with a Narrow Therapeutic Index, combinations of xanthinesProducts: PURINETHOL 50 MG TABLET, 25 ADET
  7. Drug

    Epicoccum nigrum

    go.drugbank.com/drugs/DB10434
    Approved

    Epicoccum nigrum is a fungus which can provoke allergic reactions. Epicoccum nigrum extract is used in allergenic testing.

    Mixtures: A Mold Mixture, A Mold Mixture
  8. Drug

    Pleospora herbarum

    go.drugbank.com/drugs/DB10825
    Approved

    Pleospora herbarum is a fungus which can provoke allergic reactions. Pleospora herbarum extract is used in allergenic testing.

    Mixtures: Treatment Set TS128871, Treatment Set TS129085
  9. Drug

    Sporisorium cruentum

    go.drugbank.com/drugs/DB10873
    Approved

    Sporisorium cruentum is a fungus which can provoke allergic reactions. Sporisorium cruentum extract is used in allergenic testing.

    Mixtures: Treatment Set TS128871, Treatment Set TS329906
  10. Drug

    Dexibuprofen

    go.drugbank.com/drugs/DB09213
    ApprovedWithdrawn

    Dexibuprofen, S(+)-ibuprofen, is a non-steroidal anti-inflammatory drug (NSAID). It is a pharmacologically effective enantiomer of racemic ibuprofen that differs in physicochemical properties. … It is proposed to be more pharmacologically active and tolerable with a better safety profile than ibuprofen due to higher concentration of active S enantiomer.

    Mixtures: SUITROM CAF TABLETA RECUBIERTAProducts: IBUDEX 400 FILM TABLET, 10 ADET, IBUDEX 400 FILM TABLET, 30 ADET