Search

Displaying results 221 - 230 of 2828 in total
  1. Target

    Zinc transporter ZIP2

    go.drugbank.com/bio_entities/BE0009889
    TransporterHumans

    Transporter for the divalent cation Zn(2+) (PubMed:10681536, PubMed:29791142, PubMed:30914478). Mediates the influx of Zn(2+) into cells from extracellular space. … Also transports other divalent cations Zn(2+), Cd2(+), Cu2(+), Co2(+) in the order of decreasing affinity, respectively (PubMed:29791142, PubMed:30914478).

    Polypeptides: Zinc transporter ZIP2Function: metal ion transmembrane transporter activity
  2. Target

    Zinc transporter ZIP4

    go.drugbank.com/bio_entities/BE0009894
    TransporterHumans

    Also exhibits polyspecific binding and transport of Cu(2+), Cd(2+) and possibly Ni(2+) but at higher concentrations (PubMed:22242765, PubMed:31914589) … Selective transporter that mediates the uptake of Zn(2+) (PubMed:17202136, PubMed:22242765, PubMed:27321477, PubMed:28875161, PubMed:31164399, PubMed:31914589, PubMed:31979155, PubMed:33837739, PubMed:

    Polypeptides: Zinc transporter ZIP4
  3. Target

    Zinc transporter ZIP1

    go.drugbank.com/bio_entities/BE0009902
    TransporterHumans

    Transporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space (PubMed:11301334, PubMed:12888280, PubMed:16844077).

    Polypeptides: Zinc transporter ZIP1Synonyms: Zinc-iron-regulated transporter-like
  4. Target

    Zinc transporter ZIP3

    go.drugbank.com/bio_entities/BE0009904
    TransporterHumans

    Transporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space. Controls Zn(2+) accumulation into dentate gyrus granule cells in the hippocampus.

    Polypeptides: Zinc transporter ZIP3Function: zinc ion transmembrane transporter activity
  5. Target

    Zinc transporter ZIP9

    go.drugbank.com/bio_entities/BE0009905
    TransporterHumans

    Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis (PubMed:19420709, PubMed:25014355, PubMed:28219737). … Moreover, has dual functions as a membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase

    Polypeptides: Zinc transporter ZIP9
  6. Target

    Monocarboxylate transporter 9

    go.drugbank.com/bio_entities/BE0016333
    TransporterHumans

    Extracellular pH-and Na(+)-sensitive low-affinity creatine transporter (PubMed:31784090). Also functions as a pH-independent carnitine efflux transporter (PubMed:21886157)

    Polypeptides: Monocarboxylate transporter 9Function: carnitine transmembrane transporter activity
  7. Drug

    Livmoniplimab

    go.drugbank.com/drugs/DB18939
    Investigational

    Livmoniplimab is under investigation in clinical trial NCT06109272 (A Study to Assess the Dose, Adverse Events, and Change in Disease Activity of Livmoniplimab as an Intravenous (IV) Solution in Combination With Budigalimab as an IV Solu...

    Synonyms: Immunoglobulin g4 (234-proline), anti-(human protein garp-transforming growth factor .beta.1 complex) (human monoclonal abbv-151 .gamma.4-chain), disulfide with human monoclonal abbv-151 .kappa.
  8. Drug

    Sotagliflozin

    go.drugbank.com/drugs/DB12713
    ApprovedInvestigational

    Sotagliflozin is a dual inhibitor of SGLT1 and SGLT2, the first of its kind, which is approved for use in the EU, in combination with insulin, to improve glycemic control in patients with type 1 diabetes mellitus (T1DM) and a BMI ≥27 kg/...

    Categories: Sodium-Glucose Transporter 2 Inhibitors, Sodium-Glucose Transporter 1, antagonists & inhibitors
  9. Drug

    OM-301

    go.drugbank.com/drugs/DB18198
    Experimental

    Synonyms: Pro-Pro-Leu-Ser-Gln-Gln-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu-Lys-Lys-Trp-Lys-Met- Arg-Arg-Asn-Gln-Phe-Trp-Val-Lys-Val-Gln-Arg-Gly
  10. Drug

    Paclitaxel trevatide

    go.drugbank.com/drugs/DB06171
    Investigational

    Three paclitaxel molecules linked by a cleavable succinyl ester linkage to a brain peptide vector, Angiopep-2, conjugate named ANG1005.

    Synonyms: [a-N-(2'succinyl-paclitaxel)Thr]-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-[epsilon-N-(2'succinyl-paclitaxel)Lys]-Arg-Asn-Asn-Phe-[epsilon-N-(2'succinyl-paclitaxel)Lys]-Thr-Glu-Glu-Tyr