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Irinotecan
go.drugbank.com/drugs/DB00762ApprovedInvestigational[L50181, L50186, L50201] Irinotecan liposome was approved by the FDA in February 2024.[L50186] The active metabolite SN-38 is also a potent inhibitor of DNA topoisomerase I. … This leads to the arrest of the cell cycle in the S-G2 phase and cancer cell death.[A263376]
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexSynonyms: (S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl 4-(2-(5-(3-(2,4-dihydroxy-5-isopropylphenyl)-5-hydroxy-4H-1,2,4-triazol-4-yl)-1H-indol-1-yl, )ethyl)piperidine-1-carboxylateEntacapone
go.drugbank.com/drugs/DB00494ApprovedInvestigationalEntacapone is a selective, reversible catechol-O-methyl transferase (COMT) inhibitor for the treatment of Parkinson's disease. It is a member of the class of nitrocatechols. … of levodopa and a decarboxylase inhibitor.
Mixtures: LEV/CAR/EN AL200/50/200, LEVO/CA/EN 50/12.5/200 STDCategories: Cytochrome P-450 CYP2D6 Inhibitors, Cytochrome P-450 Enzyme InhibitorsAdenosine 5'-methylenediphosphate
go.drugbank.com/drugs/DB03148ExperimentalCategories: 5'-Nucleotidase, antagonists & inhibitors, Heterocyclic Compounds, 2-RingSynonyms: Adenosine 5'-methylenediphosphate, Adenosine 5'-(hydrogen (phosphonomethyl)phosphonate)Cytidine-5'-Diphosphate
go.drugbank.com/drugs/DB04555InvestigationalCytidine 5'-(trihydrogen diphosphate). A cytosine nucleotide containing two phosphate groups esterified to the sugar moiety. Synonyms: CRPP; cytidine pyrophosphate. [PubChem]
Synonyms: Cytidine-5'-DiphosphateIndomethacin
go.drugbank.com/drugs/DB00328ApprovedInvestigationalNSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlorobenzoyl)25-methoxy-2-methylindole … Although deemed effective in reducing ocular inflammation in clinical studies, topical NSAIDs were also associated with a potential reduction in corneal sensitivity accompanied by an increased risk of
Mixtures: INDOBIOTIC GOZ DAMLASI, 5 MLCategories: P-glycoprotein inhibitors, P-glycoprotein substratesRibose-5-phosphate
go.drugbank.com/drugs/DB02053ExperimentalSynonyms: 5-O-phosphono-D-ribose, D-Ribose 5-phosphateDeoxyuridine-5'-Triphosphate
go.drugbank.com/drugs/DB02333ExperimentalSynonyms: Deoxyuridine-5'-Triphosphate