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Azathioprine
go.drugbank.com/drugs/DB00993ApprovedInvestigationalAzathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic … [L11214] Azathiprine was granted FDA approval on 20 March 1968.[L11214]
Products: AZATHIOPRIN ACIS 50MG, AZATHIOPRIN DURA N 25MGNimesulide
go.drugbank.com/drugs/DB04743ApprovedWithdrawnDue to concerns about the risk of hepatotoxicity, nimesulide has been withdrawn from market in many countries. … Its approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old.
Products: MESULID SUSPENSION PARA ADMINISTRACIÓN EN GOTAS, NIMESULIDE EGTiopronin
go.drugbank.com/drugs/DB06823ApprovedTiopronin is used as a second-line therapy to control the rate of cystine precipitation and excretion, and prevent kidney stone formation. … It is used after a failure of the non-pharmacological first line treatment consisting of increased fluid intake, restriction of sodium and protein, and urinary alkalinization.
Categories: N-substituted GlycinesProducts: Thiola ECOxybutynin
go.drugbank.com/drugs/DB01062ApprovedInvestigationalIt is often used as first-line therapy for OAB.[A185990] … efficacy since initial FDA approval in 1975.
Products: OXIBUTININA EG, Pat-oxybutynin Chloride ERHomeobox protein engrailed-2
go.drugbank.com/bio_entities/BE0004484TargetHumansSynonyms: Hu-En-2, Homeobox protein en-2Phendimetrazine
go.drugbank.com/drugs/DB01579ApprovedIllicitPhendimetrazine is chemically related to amphetamines and is a Schedule III drug under the Convention on Psychotropic Substances and in the US since 1970.
Products: Fendique ER, Phendimetrazine Tartrate ERLevosimendan
go.drugbank.com/drugs/DB00922ApprovedInvestigationalWithdrawnLevosimendan is under investigation in clinical trial NCT00527059 (Renal Effects of Levosimendan in Patients Admitted With Acute Decompensated Heart Failure). … Levosimendan increases calcium sensitivity to myocytes by binding to troponin C in a calcium dependent manner. This increases contractility without raising calcium levels.
Categories: Compounds used in a research, industrial, or household settingProducts: LEVOSIMENDAN EG, Levosimendan Carinopharm 12,5 mg Pulver für ein Konzentrat zur Herstellung einer InfusionslösungGlipizide
go.drugbank.com/drugs/DB01067ApprovedInvestigationalAccording to the 2018 Clinical Practice Guidelines by Diabetes Canada, sulfonylurea drugs are considered a second-line glucose-lowering therapy following metformin. … Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus.
Categories: Drugs Used in DiabetesSynonyms: N-{4-[β-(5-methylpyrazine-2-carboxamido)ethyl]benzenesulphonyl}-N'-cyclohexylureaAmsacrine
go.drugbank.com/drugs/DB00276ApprovedInvestigationalWithdrawnIt is effective in the treatment of acute leukemias and malignant lymphomas, but has poor activity in the treatment of solid tumors. … It is frequently used in combination with other antineoplastic agents in chemotherapy protocols. It produces consistent but acceptable myelosuppression and cardiotoxic effects.
Categories: Compounds used in a research, industrial, or household settingProducts: Amlyo 75 mg Pulver für ein Konzentrat zur Herstellung einer Infusionslösung, Amsidyl 75 mg/1,5 ml Konzentrat und Lösungsmittel für ein Konzentrat zur Herstellung einer InfusionslösungErythromycin
go.drugbank.com/drugs/DB00199ApprovedInvestigationalVet approved[L5245,L7261] It is available for administration in various forms, including intravenous, topical, and eye drop preparations.[L5245] … It was originally discovered in 1952.[L5245] Erythromycin is widely used for treating a variety of infections, including those caused by gram-positive and gram-negative bacteria.
Products: Erythro-EC, Erythro-ES