Phendimetrazine

DB01579ApprovedIllicitSmall moleculeSympathomimetic Amine Anorectic

Phendimetrazine is a sympathomimetic amine used as adjunct therapy for the short term management of exogenous obesity. Phendimetrazine is a weight loss medication.

Mechanism: Phendimetrazine may act in a similar way to amphetamines in that it activates the alpha-adrenergic system to induce an appetite suppressive and metabolic increase effect. The drug also acts as a norepinephrine-dopamine releasing agent (NDRA). It can bind to and reverse the NET.
Curator reviewed
Primary indication: Used in the management of exogenous obesity as a short term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction.Curator reviewed · 1 structured indication
Formula / weight: C₁₂H₁₇NO · 191.274 g/mol (avg)
First approval: United States, 1976
Brand names: Fendique

Resolves to

Compound

UNIIAB2794W8KVCAS634-03-7ChEMBLCHEMBL1615439ChEBI8059PubChem30487KEGGD08347

Clinical / RWD

RxNorm33272PharmGKBPA450902

Structure

InChIKeyMFOCDFTXLCYLKU-CMPLNLGQSA-NSMILESC[C@H]1[C@@H](OCCN1C)C1=CC=CC=C1

Targets

P35348ADRA1AQ01959SLC6A3P23975SLC6A2P35368ADRA1B

What you can answer from here — as of September 23, 2026

4Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

905Drug interactionsStructured to mechanism, not free text

1Clinical trialPhase, status and sponsor resolved per trial

1Structured indicationCondition, population, route and combination as fields, not prose

14ContraindicationsEach with its own population and attribute set

83Marketed productsAcross 1 country and 31 labellers

13+ReferencesStructured and connected to the statements they support

Which drugs share a target with Phendimetrazine, and which of those have an active Phase 3 trial?

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