Search

Daclizumab

The human sequences were derived from the constant domains of human IgG1 and the variable framework regions of the Eu myeloma antibody. … in de novo allogeneic renal transplantation and used concomitantly with an immunosuppressive regimen like cyclosporine and corticosteroids in patients who are not hight immunized, for commercial reasons

Gepirone

Although earlier clinical trials showed promising results for gepirone, its formulation as an immediate-release tablet necessitates frequent administration due to the short half-lives. … It was not until an extended-release formulation of gepirone was made available that gepirone became a potential candidate for a new antidepressant.

Ansuvimab

Infection with pathogenic filoviruses, such as _Zaire ebolavirus_ (Ebola virus, EBOV), can cause severe hemorrhagic fever in humans, resulting in frequent outbreaks with case fatality rates as high as … [A225933] Ansuvimab, formerly mAb114, is a fully human IgG1 mAb derived from a survivor of the 1995 Kikwit EBOV outbreak 11 years after infection, which displays strong glycan-independent binding to a

Glycolic acid

Pralsetinib

[A202055, A219751, L15986] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers, including non-small cell lung cancer. … Pralsetinib, similar to the previously approved [selpercatinib], is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.

Oxantel

Oxantel is an anthelmintic drug that targets parasitic acetylcholine receptors.[A275093, A275098]

Relacorilant

Originally investigated to manage the metabolic and endocrinologic complications of hypercortisolism, such as Cushing’s syndrome, its clinical utility has pivoted toward oncology as a potent sensitizing … Relacorilant is a first-in-class, selective glucocorticoid receptor antagonist.

Apronalide

Apronalide has been withdrawn from the market in many other countries due to patient development of thrombocytopenic purpura [A174814].

Mometasone

Mometasone is a corticosteroid not currently used in medical products. [Mometasone furoate] however, is still in use.

Danicopan

[A263501,L50411] Danicopan is a small molecule complement factor D inhibitor that selectively blocks the alternative pathway, thereby working to address extravascular hemolysis when used in conjunction … Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired hematologic disease characterized by hemolysis, thrombophilia, and bone marrow dysfunction.