Gepirone

DB12184ApprovedSmall molecule

Gepirone is a serotonin receptor agonist used to treat major depressive disorder in adults. Gepirone, an azapirone, is a pharmacologic analog of buspirone that acts selectively on the pre- and post-synaptic 5HT1A receptors.

Mechanism: The mechanism of the antidepressant effect of gepirone is not fully understood but is thought to be related to its modulation of serotonergic activity in the CNS through selective agonist activity at 5HT1a receptors. Particularly, gepirone
Curator reviewed · 1 reference
Primary indication: Gepirone is indicated for the treatment of major depressive disorder (MDD) in adults.Curator reviewed · 1 structured indication
Formula / weight: C₁₉H₂₉N₅O₂ · 359.474 g/mol (avg)
First approval: United States, 2024
Brand names: Exxua

Resolves to

Compound

UNIIJW5Y7B8Z18CAS83928-76-1ChEMBLCHEMBL284092ChEBI135990PubChem55191

Clinical / RWD

RxNorm2672253ATCN06AX19

Structure

InChIKeyQOIGKGMMAGJZNZ-UHFFFAOYSA-NSMILESCC1(C)CC(=O)N(CCCCN2CCN(CC2)C2=NC=CC=N2)C(=O)C1

Targets

P08908HTR1A

What you can answer from here — as of September 13, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

1,164Drug interactionsStructured to mechanism, not free text

1Clinical trialPhase, status and sponsor resolved per trial

1Structured indicationCondition, population, route and combination as fields, not prose

6ContraindicationsEach with its own population and attribute set

8Marketed productsAcross 1 country and 2 labellers

1ATC codeIncluding every combination product, plus 15 drug categories

14+ReferencesStructured and connected to the statements they support

Which drugs share a target with Gepirone, and which of those have an active Phase 3 trial?

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