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Pibrentasvir
go.drugbank.com/drugs/DB13878ApprovedInvestigationalIn clinical trials, this combination therapy achieved SVR12 rate, or undetectable Hepatitis C for twelve or more weeks after the end of treatment, of ≥93% across genotypes 1a, 2a, 3a, 4, 5 and 6 [L940] … This fixed-dose combination therapy was FDA-approved in August 2017 to treat adults with chronic hepatitis C virus (HCV) genotypes 1-6 without cirrhosis (liver disease) or with mild cirrhosis, including
Mixtures: MAVIRET® 100/40 MG TABLETAS RECUBIERTAS, MAVİRET 100 MG/40 MG FİLM KAPLI TABLET, 84 ADETCategories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP1A2 InhibitorsDiloxanide furoate
go.drugbank.com/drugs/DB14638ApprovedInvestigationalSynonyms: 2,2-dichloroacetamido-4-n-methylphenyl 2-furoate, 4-(n-methyl-2,2-dichloroacetamido)phenyl 2-furoateCategories: Heterocyclic Compounds, 1-RingNADH
go.drugbank.com/drugs/DB00157ApprovedNutraceuticalIt forms NADP with the addition of a phosphate group to the 2' position of the adenosyl nucleotide through an ester linkage. (Dorland, 27th ed) … NADH is the reduced form of NAD+, and NAD+ is the oxidized form of NADH, a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.
Mixtures: HEPATAMINE %8 500 ML(SETLI), HEPATAMINE %8 500 ML(SETSIZ)Categories: Heterocyclic Compounds, 2-RingBazedoxifene
go.drugbank.com/drugs/DB06401ApprovedInvestigationalBazedoxifene is a third generation selective estrogen receptor modulator (SERM), developed by Pfizer following the completion of their takeover of Wyeth Pharmaceuticals. … In 2013, the combination product containing conjugated estrogens and bazedoxifene was approved by the FDA for the treatment of moderate to severe vasomotor symptoms associated with menopause, as well as
Mixtures: DUAVIVE 20 mg/0.45 mg modified - release tablets, DUAVİVE 0.45 MG/20 MG DEĞİŞTİRİLMİŞ SALIMLI TABLET, 30 TABLETCategories: Heterocyclic Compounds, 2-Ring, Genito Urinary System and Sex HormonesGenistein
go.drugbank.com/drugs/DB01645InvestigationalIt has been determined to be the active ingredient in <I>Felmingia vestita</I>, which is a plant traditionally used against worms. … Further, genistein is a phytoestrogen which has selective estrogen receptor modulator properties.
Synonyms: 4H-1-BENZOPYRAN-4-ONE, 5,7-DIHYDROXY-3-(4-HYDROXYPHENYL)-, 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-oneMixtures: CALCIDAY G 1200 MG/800 IU/50 MG EFERVESAN TABLET, 45 ADET, CALCİDAY G 1000 MG/880 IU/50 MG EFERVESAN TABLET, 40 ADETThioproperazine
go.drugbank.com/drugs/DB01622ApprovedThioproperazine is a potent neuroleptic with antipsychotic properties. … Thioproperazine has a marked cataleptic and antiapomorphine activity associated with relatively slight sedative, hypothermic and spasmolytic effects.
Synonyms: N,N-Dimethyl-10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine-2-sulfonamide, N,N-Dimethyl-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine-2-sulfonamideCategories: Heterocyclic Compounds, 3-Ring, Adrenergic alpha-1 Receptor AntagonistsBelumosudil
go.drugbank.com/drugs/DB16703ApprovedInvestigational[A236634] It is an inhibitor of rho-associated coiled-coil-containing protein kinases (ROCK), with significantly more selectivity for ROCK2 as compared to ROCK1 (IC<sub>50</sub> 100 nM vs. 3 μM, respectively … immune dysregulation by shifting the balance between Th17 cells and T-regulatory cells, thereby dampening the inflammatory cascade that can occasionally be fatal.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsMetabolism and Phsyiological Effects of Asymmetric dimethylarginine (ADMA)
smpdb.ca/view/SMP0124747MetabolicAsymmetrical dimethylarginine (ADMA) is produced from L-arginine. L-arginine is obtained from protein-rich foods like red meat, poultry, dairy and eggs. It is absorbed in the intestine to the blood. It enters cells in the body and is met...
Enzymes: Y+L amino acid transporter 1Mevastatin
go.drugbank.com/drugs/DB06693ExperimentalMevastatin is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself. … Two years later, the research group isolated a compound structurally similar to hydroxymethylglutarate (HMG) that inhibited the incorporation of acetate.
Cretostimogene grenadenorepvec
go.drugbank.com/drugs/DB05148InvestigationalCG0070 is a solid. CG0070 can potentially destroy cancer cells by two different mechanisms: direct cell killing by the virus and immune-mediated cell killing stimulated by GM-CSF. … It has been engineered to secrete GM-CSF, an immune stimulating hormone, which also serves as the adjuvant in cancer immunotherapy.