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Mercaptopurine
go.drugbank.com/drugs/DB01033ApprovedInvestigationalIt interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
Categories: Drugs for Obstructive Airway DiseasesMilnacipran
go.drugbank.com/drugs/DB04896ApprovedInvestigationalMilnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) and like many agents in this category was originally developed for and continues to be approved and indicated for the treatment … Moreover, recent research has shown that the levorotatory enantiomer of milnacipran, levomilnacipran, may have the capacity to inhibit the activity of beta-site amyloid precursor protein cleaving enzyme
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeOmega-3-carboxylic acids
go.drugbank.com/drugs/DB09568ApprovedWithdrawnThe increased bioavailability is explained because OM3-CA is found in a form of polyunsaturated free fatty acids as opposed to other products whose form is as ethyl esters. … [A25808] It was developed by AstraZeneca Pharmaceuticals and firstly approved by the FDA on May 05, 2014.[L2386]
Leflunomide
go.drugbank.com/drugs/DB01097ApprovedInvestigationalLeflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. … Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999.
Evinacumab
go.drugbank.com/drugs/DB15354ApprovedInvestigational[L31838] In September and December 2023, evinacumab was also approved by Health Canada and EMA, respectively, for the same indication.[L49956,L49966] … [A229278] In February 2021, evinacumab became the first-and-only inhibitor of ANGPTL3 to receive FDA approval after it was granted approval for the adjunctive treatment of homozygous familial hypercholesterolemia
Thymidine
go.drugbank.com/drugs/DB04485ApprovedInvestigational[A274683] While it lacks significant anti-tumor activity on its own,[A274688] it has been extensively investigated for nearly a decade as a biochemical modulator to enhance the efficacy and reduce the … Thymidine is a naturally occurring deoxyribonucleoside that is a crucial component of the DNA salvage pathway and a building block for DNA synthesis.
Dezocine
go.drugbank.com/drugs/DB01209ApprovedInvestigationalDezocine is a partial opiate drug and is used for pain management. … Dezocine is a very effective alternative to fentanyl when administered during outpatient laparoscopy, although is associated with an increased incidence of postoperative nausea.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeValaciclovir
go.drugbank.com/drugs/DB00577ApprovedInvestigationalValaciclovir (valacyclovir), also known as _Valtrex_, is an antiviral drug that has been used to manage and treat various herpes infections for more than 2 decades. … It was initially approved by the FDA in 1995 [FDA label] and marketed by GlaxoSmithKline [L5671]. Valacyclovir is the L-valine ester of aciclovir.
Categories: Antivirals for Systemic Use, Antiinfectives for Systemic UseProducts: Co ValacyclovirProcaine
go.drugbank.com/drugs/DB00721ApprovedInvestigationalVet approvedIt is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).
Mixtures: Sterile Concentrate For Cardioplegia InfusionCategories: Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use, Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeDermatophagoides farinae
go.drugbank.com/drugs/DB10400ApprovedInvestigationalThis combination is approved for as a year-round, once-a-day tablet that's dissolved under the tongue as a treatment for dust mite allergies. … Dermatophagoides farinae extracts are sterile solutions used for intradermal testing or subcutaneous immunotherapy.
Products: Standardized Mite, Dermatophagoides farinae, Scratch or Bulk, 30000 AU per mL