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Pixantrone
go.drugbank.com/drugs/DB06193ApprovedWithdrawnAnother phase III trial, PIX-R, is now ongoing to clarify pixantrones place in therapy. It will compare pixantrone efficacy to that of gemcitabine. [2] … Based on this uncertainty, in 2009, the FDA ultimately rejected Cell Therapeutic's initial application for accelerated approval for pixantrone use in relapsed or refractory NHL.
Synonyms: 6,9-bis((2-aminoethyl)amino)benzo(g)isoquinoline-5,10-dione20-ketosteroid reductase (20-hydroxysteroid dehydrogenase)
go.drugbank.com/bio_entities/BE0009795EnzymeHumans and other mammalsCatalyzes the inactivation of 5alpha-DHT and progesterone converting them into 3alpha/beta-androstanediols and (20S)-hydroxypregn-4-en-3-one, respectively (PubMed:10998348, PubMed:24434280). … Catalyzes the reduction of progesterone to less potent progestogen (20S)-hydroxypregn-4-en-3-one likely regulating ligand availability for progesterone receptors (PubMed:10998348, PubMed:11013348, PubMed
Synonyms: 20-alpha-HSDFunction: 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activityPotassium cation
go.drugbank.com/drugs/DB01345ApprovedThe balance between potassium and sodium is maintained by ion pumps in the cell membrane. … The concentration differences of these charged particles causes a difference in electric potential between the inside and outside of cells, known as the membrane potential.
Mixtures: POLİFLEKS LAKTATLI RİNGER IV İNFÜZYON İÇİN ÇÖZELTİ, 2000 ML (PVC TORBA) SETLI, POLİFLEKS LAKTATLI RİNGER IV İNFÜZYON İÇİN ÇÖZELTİ, 2000 ML (PVC TORBA) SETSİZPhenylpropanolamine
go.drugbank.com/drugs/DB00397ApprovedVet approvedWithdrawnCurrently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes.
Mixtures: PAROL COLD 325 MG KAPSUL, 20 ADET, COUGH - ENBrivoligide
go.drugbank.com/drugs/DB16116InvestigationalBrivoligide is under investigation in clinical trial NCT04104919 (Study to Evaluate a Preop Dose of Brivoligide Injection for Pain After Mastectomy in Patients With High PCS Scores).
Synonyms: D(c-t-a-c-g-c-c-c-a-c-c-g-c-c-c-a-c-g-c-a-t-a-c), complex with dna d(g-t-a-t-g-c-g-t-g-g-g-c-g-g-t-g-g-g-c-g-t-a-g) (1:1), Dna, d(c-t-a-c-g-c-c-c-a-c-c-g-c-c-c-a-c-g-c-a-t-a-c), complex with dna d(g-t-a-t-g-c-g-t-g-g-g-c-g-g-t-g-g-g-c-g-t-a-g) (1:1)Nalmefene
go.drugbank.com/drugs/DB06230ApprovedInvestigationalWithdrawn[L40684] It acts as an antagonist at the mu (μ)-opioid and delta (δ)-opioid receptors and a partial agonist at the kappa (κ)-opioid receptor. … [L1024] In Europe, nalmefene oral tablets are used to reduce alcohol consumption in adults with alcohol dependence.
Categories: Drugs Used in Alcohol Dependence, Drugs Used in Addictive DisordersMycobacterium avium complex infection
go.drugbank.com/conditions/DBCOND0013995Synonyms: Mycobacterium avium complex, Mycobacterium avium complex infectionBamlanivimab
go.drugbank.com/drugs/DB15718ApprovedInvestigational[L20979] Based on phase 2 clinical trial (BLAZE-1) interim results, bamlanivimab was granted Emergency Use Authorization (EUA) by the FDA on November 10, 2020. … it in collaboration with Eli Lilly and Company.
Setmelanotide
go.drugbank.com/drugs/DB11700ApprovedInvestigational[A224449] Imcivree was granted EMA orphan designation on November 19, 2018 [L24559] and FDA approval on November 25, 2020.[L24429] On May 4, 2023, it was approved by Health Canada.[L46327] … [A224449] Patients taking setmelanotide experienced an average weight loss of 0.6 kg/week.
Antipyrine
go.drugbank.com/drugs/DB01435ApprovedAn analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. … (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
Mixtures: PASSEAR 45.52 MG+11.38 MG/ML KULAK DAMLASI, ÇÖZELTİ, SUPRENIL STERIL OFTALMIK SUSPANSIYON 5 ML