Antipyrine

DB01435ApprovedSmall molecule

Antipyrine is an antipyretic agent used for the symptomatic treatment of acute otitis media, most commonly in combination with benzocaine. An analgesic and antipyretic that has been given by mouth and as ear drops.

Mechanism: Antipyrine is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin (PG) synthesis.
Curator reviewed
Primary indication: Antipyrine is an analgesic often used to test effects of other drugs on liver enzymes.Curator reviewed · 4 structured indications
Formula / weight: C₁₁H₁₂N₂O · 188.2258 g/mol (avg)
First approval: Canada, 2003
Also known as: Analgesine · Phenazon · Phenazone

Resolves to

Compound

UNIIT3CHA1B51HCAS60-80-0ChEMBLCHEMBL277474ChEBI31225PubChem2206KEGGD01776

Clinical / RWD

RxNorm1001ATCN02BB01ATCN02BB51ATCN02BB71PharmGKBPA448453

Structure

InChIKeyVEQOALNAAJBPNY-UHFFFAOYSA-NSMILESCN1N(C(=O)C=C1C)C1=CC=CC=C1

Targets

P23219PTGS1P35354PTGS2

Transporters

Q4U2R8SLC22A6

What you can answer from here — as of September 23, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

1TransporterSubstrate / inhibitor direction, not just membership

Listed above

1,884Drug interactionsStructured to mechanism, not free text

3Clinical trialsPhase, status and sponsor resolved per trial

4Structured indicationsCondition, population, route and combination as fields, not prose

1ContraindicationEach with its own population and attribute set

59Marketed productsAcross 6 countries and 46 labellers

4ATC codesIncluding every combination product, plus 33 drug categories

31+ReferencesStructured and connected to the statements they support

Which drugs share a target with Antipyrine, and which of those have an active Phase 3 trial?

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