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Sipuleucel-T
go.drugbank.com/drugs/DB06688ApprovedInvestigationalSipuleucel-T was approved by the U.S. Food and Drug Administration (FDA) on April 29, 2010, to treat asymptomatic or minimally symptomatic metastatic Hormone-Refractory Prostate Cancer (HRPC). … The treatment initially cost $93,000 at the time of FDA approval, but rose to over $100,000 in 2014.
Categories: Antineoplastic and Immunomodulating AgentsNaldemedine
go.drugbank.com/drugs/DB11691ApprovedInvestigationalNaldemedine was approved in 2017 in both the US and Japan for the treatment of Opioid-induced Constipation. … It is a modified form of [DB00704] to which a side chain has been added to increase molecular weight and polar surface area resulting in restricted transport across the blood brain barrier.
Categories: Alimentary Tract and MetabolismDaclatasvir
go.drugbank.com/drugs/DB09102ApprovedInvestigationalWithdrawnIt is marketed under the name DAKLINZA and is contained in daily oral tablets as the hydrochloride salt form . … The most common critical NS5A amino acid substitutions that led to reduced susceptibility to daclatasvir therapy occured at position Q30 (Q30H/K/R) and M28 in genotype 1a patients and Y93H in genotype
Categories: Amino Acids, Peptides, and Proteins, daclatasvir, asunaprevir and beclabuvirProducts: DAKLINZA TABLET 30MG, DAKLINZA TABLET 60MGQuazepam
go.drugbank.com/drugs/DB01589ApprovedIllicitIt was first approved in the US in 1985 and is used as a hypnotic for the treatment of insomnia. … [L44913] It appears to be unique amongst other benzodiazepine derivatives in its relatively high affinity for sleep-promoting α1 subunit-containing GABA<sub>A</sub> receptors and low affinity for other
Categories: Hypnotics and Sedatives, Benzodiazepine hypnotics and sedativesDeep vein thrombosis recurrent
go.drugbank.com/conditions/DBCOND0025031Synonyms: Acute embolism and thrombosis of unspecified deep veins of lower extremityPotassium
go.drugbank.com/drugs/DB14500ApprovedInvestigationalPotassium is an essential nutrient, like [Calcium] and [Magnesium]. It was identified as a shortfall nutrient by the 2015-2020 Advisory Committee of Dietary Guidelines for Americans. … They are available in an assortment of tablet, injection, and other forms, depending on the setting and condition being treated.
Synonyms: KMixtures: CALCIUM AND MAGNESIUM PLUS C,POTASSIUM AND ZINC TABLET, Potassium and Iodine TabLoncastuximab tesirine
go.drugbank.com/drugs/DB16222ApprovedInvestigational[L45206] This therapy was developed by ADC Therapeutics and its accelerated approval for relapsed or refractory B-cell lymphoma is based on promising results from the LOTIS-2 clinical trial. … [A234439] Prognosis is poor and more effective therapies are needed to treat relapsed/refractory cases and improve survival.
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsChondroitin sulfate
go.drugbank.com/drugs/DB09301ApprovedInvestigationalNutraceutical[A32063] Chondroitin sulfate is sold as an OTC dietary supplement in North America and it is a prescription drug under the EMA in Europe.[A32066] … Chondroitin sulfate is composed of alternating 1,3-N-acetyl-β-d-galactosamine and 1,4-β-d-glucuronic acid units which bear 4-O- and/or 6-O-sulfations at the N-acetylgalactosamine units disposed of in specific
Mixtures: Blackmores Joint Formula with Glucosamine and ChondroitinCategories: Antiinflammatory and Antirheumatic Products, Antiinflammatory and Antirheumatic Products, Non-SteroidsInflammatory Bowel Diseases (IBD)
go.drugbank.com/conditions/DBCOND0069946Drugs: PhthalylsulfathiazoleSynonyms: (Noninfective enteritis and/or colitis) or (inflammatory bowel disease) or (noninfective diarrhoea)Picosulfuric acid
go.drugbank.com/drugs/DB09268ApprovedInvestigationalThe combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been used in European countries for many years.[A33322]
Mixtures: Riva-magnesium Oxide, Citric Acid and Sodium Picosulfate, Sodium Picosulfate, Magnesium Oxide and Anhydrous Citric AcidCategories: Alimentary Tract and Metabolism