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Bimekizumab
go.drugbank.com/drugs/DB12917ApprovedInvestigational[L39665,L39680] It is the first IL-17 inhibitor to target both IL-17A and IL-17F. … [A244455] It has demonstrated superior efficacy as compared to another IL-17 inhibitor, [secukinumab], as well as [ustekinumab] (an IL-12/23 inhibitor) and [adalimumab] (a TNF inhibitor) in the treatment
Technetium Tc-99m mebrofenin
go.drugbank.com/drugs/DB09137ApprovedWithdrawnThis is possible as Technetium-99m decays by isomeric transition to technetium-99 through the release of a gamma ray. … Technetium Tc 99m Mebrofenin is a diagnostic radiopharmaceutical composed of diisopropyl-iminodiacetic acid (DISIDA) attached to a technetium-99m ion.
Categories: Compounds used in a research, industrial, or household settingSynonyms: Bis(2-[[2-(3-bromo-2,4,6-trimethylanilino)-2-oxoethyl]-(carboxymethyl)amino]acetate) technetium, Technetium Tc 99m DISIDALifileucel
go.drugbank.com/drugs/DB17107ApprovedInvestigationalLifileucel is a tumour-derived autologous T cell immunotherapy composed of a suspension of tumour-derived T cells from the patient [L50171] which undergo isolation, ex vivo expansion, and activation[A263341 … ] Lifileucel was granted accelerated approval by the FDA on February 16, 2024, for the treatment of unresectable or metastatic melanoma.
Bremelanotide
go.drugbank.com/drugs/DB11653Approved[A179686] The mechanism by which bremelanotide's action on receptors translates to a clinical effect is still unknown. … Bremelanotide is a 7 amino acid peptide used to treat hypoactive sexual desire disorder in premenopausal women.[L9635] Bremelanotide does not interact with alcohol.
Categories: Receptor, Melanocortin, Type 3, agonists, Receptor, Melanocortin, Type 4, agonistsDiflunisal
go.drugbank.com/drugs/DB00861ApprovedDiflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. … Diflunisal is used to relieve pain accompanied with inflammation and in the symptomatic treatment of rheumatoid arthritis and osteoarthritis.
Synonyms: 2',4'-difluoro-4-hydroxy-3-biphenylcarboxylic acid, 2-(hydroxy)-5-(2,4-difluorophenyl)benzoic acidCategories: Non COX-2 selective NSAIDSPipradrol
go.drugbank.com/drugs/DB11584ApprovedWithdrawnIt is currently classified under the Misuse of Drugs Act as a Class C substance [L2522]. … Pipradrol (Meratran) [L2523] was initially developed in the 1950s as an antidepressant, however, the adverse effects associated with its use and its abuse potential led to its withdrawal and international
Categories: Heterocyclic Compounds, 1-RingOxaprozin
go.drugbank.com/drugs/DB00991ApprovedOxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis.
Categories: Non COX-2 selective NSAIDS, Heterocyclic Compounds, 1-RingProducts: DILOX®, DURAPROX®Tavaborole
go.drugbank.com/drugs/DB09041ApprovedTavaborale is a novel, boron-based topical antifungal medication for the treatment of onychomycosis, a fungal infection of the nail and nail bed due to *Trichophyton rubrum* or *Trichophyton mentagrophytes … Tavaborole functions by inhibiting Leucyl-tRNA synthetase, or LeuRS, an essential fungal enzyme required for protein synthesis and for the catalysis of ATP-dependent ligation of L-leucine to tRNA(Leu).
Synonyms: 5-Fluoro-2,1-benzoxaborol-1(3H)-ol, 5-Fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaboroleLutetium Lu 177 dotatate
go.drugbank.com/drugs/DB13985ApprovedInvestigationalLutetium Lu 177 dotatate may also be referred to as 177Lu-DOTA-Tyr3-octreotate. … It is a first radiopharmaceutical agent to be approved for gastroenteropancreatic neuroendocrine tumors (GEP-NETs) and is indicated for adult patients with somatostatin receptor-positive GEP-NETs [L1191
Synonyms: 177-Lu DOTA-0-Tyr3-OctreotateCategories: Compounds used in a research, industrial, or household settingMoclobemide
go.drugbank.com/drugs/DB01171ApprovedInvestigationalA reversible monoamine oxidase inhibitor (MAOI) selective for isoform A (RIMA) used to treat major depressive disorder. … Most meta-analyses and most studies indicate that in the acute management of depression, moclobemide is more efficacious than placebo medication and similarly efficacious as tricyclic antidepressants (
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Cytochrome P-450 SubstratesSynonyms: 4-Chlor-N-(2-morpholinoethyl)benzamid, p-Chloro-N-(2-morpholinoethyl)benzamide