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Vamorolone
go.drugbank.com/drugs/DB15114ApprovedInvestigational[L48671,L48676] In December 2023, it was approved in the EU for the treatment of patients ≥4 years of age.[L49505] … Vamorolone is a novel and fully synthetic glucocorticoid developed by Santhera Pharmaceuticals.
Categories: Sex Hormones and Insulins, Cytochrome P-450 SubstratesChlorophyll B
go.drugbank.com/drugs/DB04506ExperimentalA light, silvery, metallic element. It has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. … (From Dorland, 27th ed)
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds with 4 or More RingsSynonyms: Chlorophyll BFloxuridine
go.drugbank.com/drugs/DB00322ApprovedInvestigationalAn antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection. Floxuridine is available as a sterile, nonpyrogenic, lyophilized powder for reconstitution. … When administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate.
Categories: Cytochrome P-450 CYP2C9 Inhibitors, Cytochrome P-450 Enzyme InhibitorsSynonyms: 1-(2-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil, 1-beta-D-2'-Deoxyribofuranosyl-5-flurouracilMiocamycin
go.drugbank.com/drugs/DB13287ApprovedMiocamycin is a macrolide type antimicrobial [A176170]. This drug may be marketed in Japan for clinical use as it is listed in the Japanese pharmacopeia [L5737].
Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 InhibitorsMedrogestone
go.drugbank.com/drugs/DB09124ApprovedWithdrawnMedrogestone (INN), also known as 6,17α-dimethyl-6-dehydroprogesterone, is a progestational agent derived from 17-methylprogesterone. … [A31526] It was developed by Ayerst, approved in Canada in 1969 and its current status is cancelled post-marketing.[L1118] It was never approved by the FDA.
Mixtures: PRESOMEN 28 COMP 0.3/5MG, PRESOMEN 28 COMP 0.3/5MGCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesAmivantamab
go.drugbank.com/drugs/DB16695ApprovedInvestigational[A235103,A235123] Patients with NSCLC with exon 20 insertion mutations in EGFR do not respond to tyrosine kinase inhibitors, and were generally treated with platinum-based therapy. … [A235133] Amivantamab was granted FDA approval on 21 May 2021,[L34193] followed by the approval by the EMA on 9 December 2021 [L41474] and Health Canada on 30 March 2022.
Tislelizumab
go.drugbank.com/drugs/DB14922ApprovedInvestigational[A262924] On September 25, 2023, tislelizumab gained EMA approval as a monotherapy for adults with esophageal cancer under the brand name TEVIMBRA. … [L49439] Tislelizumab was also approved by the FDA on March 14, 2024.[L50346] It has subsequently been approved for additional cancers in the US and EU. [L49349]
Categories: PD-1/PDL-1 (Programmed cell death protein 1/death ligand 1) inhibitors, PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitorsHexocyclium
go.drugbank.com/drugs/DB06787ApprovedIt was once available under the tradename Tral marketed by Abbvie Inc. but has been discontinued. … Hexocyclium is a muscarinic acetylcholine receptor antagonist which was presumably used in the treatment of gastric ulcer or diarrhea.
Categories: Heterocyclic Compounds, 1-RingCopanlisib
go.drugbank.com/drugs/DB12483ApprovedInvestigationalCopanlisib is a selective pan-Class I phosphoinositide 3-kinase (PI3K) inhibitor with preferential activity against the alpha and delta isoforms. … [A261730] Copanlisib was granted accelerated approval by the FDA in September 2017 for the treatment of follicular lymphoma.[A261725]
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: 2-AMINO-N-(7-METHOXY-8-(3-(MORPHOLIN-4-YL)PROPOXY)-2,3-DIHYDROIMIDAZO(1,2-C)QUINAZOLIN-5-YL(PYRIMIDINE-5-CARBOXAMIDE, 2-AMINO-N-(7-METHOXY-8-(3-MORPHOLIN-4-YLPROPOXY)-2,3-DIHYDROIMIDAZO(1,2-C)QUINAZOLIN-5-YL)PYRIMIDINE-5-CARBOXAMIDEEthynodiol diacetate
go.drugbank.com/drugs/DB00823ApprovedAlthough etynodiol or ethynodiol are sometimes used as a synonym for ethynodiol diacetate, what is usually being referred to is actually ethynodiol diacetate and not ethynodiol (which is a separate drug … A synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive.
Mixtures: Kelnor 1/50, Valtya 1/50Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates