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Ozenoxacin
go.drugbank.com/drugs/DB12924Approveds Xepi (ozenoxacin 1%) as a topically applied cream indicated for the treatment of impetigo caused by *Staphylococccus aureus* or *Streptococcus pyogenes* in adult and pediatric patients 2 months of age … Despite being a common and highly contagious bacerial skin infection that affects millions of children and adults in the United States each year, ozenoxacin cream is a novel, non-fluorinated quinolone
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingLeptin
go.drugbank.com/drugs/DB05098InvestigationalAlthough leptin is a circulating signal that reduces appetite, in general, obese people have an unusually high circulating concentration of leptin. … Thus, obesity develops when people take in more energy than they use over a prolonged period of time, and this excess food intake is not driven by hunger signals, occurring in spite of the anti-appetite
Telisotuzumab vedotin
go.drugbank.com/drugs/DB15104ApprovedInvestigationalTelisotuzumab vedotin is an antibody-drug conjugate comprising [telisotuzumab], a c-Met-directed humanized IgG1κ monoclonal antibody, conjugated to monomethyl auristatin E (MMAE), a small molecule microtubule-disrupting … [L53158] The c-Met protein is found to be overexpressed in approximately 25% of advanced EGFR wild type, non-squamous NSCLC patients and is associated with poor prognosis and limited treatment options.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsPemigatinib
go.drugbank.com/drugs/DB15102ApprovedInvestigationalPemigatinib is a small molecule kinase inhibitor with antitumour activity. … Pemigatinib is marketed under the brand name Pemazyre, and it is available as oral tablets.[L13050]
Categories: MATE 1 Inhibitors, Cytochrome P-450 SubstratesGadoversetamide
go.drugbank.com/drugs/DB00538ApprovedGadoversetamide, marketed under the trade name OptiMARK, is a gadolinium compound used as a contrast agent in magnetic resonance imaging (MRI), particularly imaging of the brain, spine and liver.
Categories: Compounds used in a research, industrial, or household settingMagnesium salicylate
go.drugbank.com/drugs/DB01397Approved), effective pain relief is often found with a half dosage, with reduced anti-inflammatory results. … Magnesium salicylate is a non-steroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain. It is available in several over-the-counter (OTC) formulations.
Categories: Non COX-2 selective NSAIDSProducts: Back-ese M Tab 325mg, Back-ese M Tablets 325 mgEtirinotecan pegol
go.drugbank.com/drugs/DB14951InvestigationalEtirinotecan pegol is under investigation in clinical trial NCT01663012 (Phase II NKTR-102 In Bevacizumab-Resistant High Grade Glioma).
Categories: Topoisomerase II Inhibitors, Topoisomerase 1 (TOP1) inhibitorsIdecabtagene vicleucel
go.drugbank.com/drugs/DB16665ApprovedInvestigationalMultiple myeloma is a cancer where plasma cells rapidly divide out of control. … [A232563] These cancerous cells generally express the B-cell maturation antigen, while it is rarely expressed on non-cancerous cells.
Synonyms: Anti-BCMA CAR T cellCategories: Receptors, Antigen, T-CellSugammadex
go.drugbank.com/drugs/DB06206ApprovedInvestigationalSugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery. … Sugammadex (brand name Bridion) is marketed by Merck Sharp and Dohme, and was approved by the United States FDA on December 15, 2015.
Categories: Compounds used in a research, industrial, or household settingProducts: MIGAD-X, BRIDION® 200 MG/2 ML SOLUCIÓN PARA INYECCIÓNLetibotulinumtoxinA
go.drugbank.com/drugs/DB16820Approved[L42330] It is a 900 kDa multimeric complex comprising a 150 kDa toxin, a 130 kDa non-toxic non-haemagglutinating protein, and various other haemagglutinins. … [A249920] LetibotulinumtoxinA is a type A botulinum neurotoxin produced from fermentation of _Clostridium botulinum_ strain CBFC26.
Synonyms: BoNT/A-DSCategories: Botulinum Toxins, Type A