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Prednicarbate
go.drugbank.com/drugs/DB01130ApprovedThe anti-inflammation action of corticosteroids is associated with the inhibition of the interleukin 1-alpha cytokine within keratinocytes. … It has a favorable benefit-risk ratio, with an inflammatory action similar to that of a medium potency corticosteroid, but with a low potential to cause skin atrophy.
Categories: Corticosteroid Hormone Receptor AgonistsInternational brands: Dermatop E EmollientPipotiazine
go.drugbank.com/drugs/DB01621ApprovedInvestigationalWithdrawnAmong the different phenothiazine derivatives, it appears to be less sedating and to have a weak propensity for causing hypotension or potentiating the effects of CNS depressants and anesthetics. … Pipotiazine has actions similar to those of other phenothiazines.
Categories: Dopamine D2 Receptor Antagonists, Serotonin Receptor AntagonistsAsparaginase Escherichia coli
go.drugbank.com/drugs/DB00023ApprovedInvestigationalFor patients who develop hypersensitivity to _E. coli_-derived formulations of L-asparaginase, the use of PEGylated or non-PEGylated [DB08886] is recommended [A31999]. … Asparaginase from _E. coli_ has clinically shown to exhibit antitumor actions in models of leukaemias [A31996, A31997].
Synonyms: Asparaginase (E. coli), E. coli AsparaginaseFaricimab
go.drugbank.com/drugs/DB15303ApprovedInvestigationalHowever, another set of factors, the Tie/Ang axis, comprising the transmembrane Tie-2 receptor and its soluble ligands Ang-1 and Ang-2, has been shown to play critical roles in mediating VEGF-A-induced … [L42305] In July 2022, the EMA's Committee for Medicinal Products for Human Use (CHMP) recommended faricimab be granted marketing authorization for the treatment of neovascular age-related macular degeneration
Isotretinoin
go.drugbank.com/drugs/DB00982ApprovedInvestigational[L6574] Isotretinoin is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the United States. … [L6579] The first isotretinoin-containing product was FDA approved on 7 May 1982.[L6574]
Synonyms: (7E,9E,11E,13Z)-retinoic acidDihydroergocristine
go.drugbank.com/drugs/DB13345Approved[A32879] To know more about ergoloid mixtures, please visit [DB01049]. … Dihydroergocristine is part of the ergoloid mixture products.[L2637] It is a semisynthetic ergot alkaloid and thus, it is characterized by a structural skeleton formed by an alkaloid ergoline.
Quinupristin
go.drugbank.com/drugs/DB01369ApprovedDalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome and quinupristin inhibits the late phase of protein synthesis. … The combination of the two components acts synergistically and is more effective in vitro than each component alone.
Danicopan
go.drugbank.com/drugs/DB15401ApprovedInvestigational[A263501,L50417] Both hemolysis and thrombophilia are mediated primarily by the complement system.[A263501] Standard therapy for PNH involves the use of complement C5 inhibitors (e.g. … [A263506] It was subsequently approved by the FDA in March 2024.[L50386]
Eptinezumab
go.drugbank.com/drugs/DB14040ApprovedInvestigational[L12318] Eptinezumab has been specifically designed to bind to both alpha and beta forms of the human calcitonin gene-related peptide (CGRP). … [F94,A33105,A33106,A33108] It was approved by the FDA in February 2020 for the preventive treatment of migraine headaches in adults.[L12318]
Oxethazaine
go.drugbank.com/drugs/DB12532ApprovedWithdrawn[L1113] It is also in the list of approved derivatives of herbal products by the EMA.[L2816] … Its actions have shown to relieve dysphagia, relieve pain due to reflux, chronic gastritis, and duodenal ulcer.