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Polatuzumab vedotin
go.drugbank.com/drugs/DB12240ApprovedInvestigational(mc-vc-PAB) that covalently attaches MMAE to polatuzumab. … Polatuzumab vedotin is a CD79b-directed antibody-drug conjugate that delivers monomethyl auristatin E (MMAE), an anti-mitotic agent, to cancer cells.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesPolyethylene glycol 300
go.drugbank.com/drugs/DB11161ApprovedPolyethylene glycol 300 (PEG 300) is a water-miscible polyether with an average molecular weight of 300 g/mol. … PEG 300 is found in eye drops as a lubricant to temporarily relieve redness, burning and irritation of the eyes.
Categories: P-glycoprotein inhibitors, Compounds used in a research, industrial, or household settingSynonyms: PEG-6, PEG 300Solute carrier family 25 member 32
go.drugbank.com/bio_entities/BE0000730TransporterHumansFacilitates flavin adenine dinucleotide (FAD) translocation across the mitochondrial inner membrane into the mitochondrial matrix where it acts as a redox cofactor to assist flavoenzyme activities in fundamental metabolic processes inclu...
Polypeptides: Solute carrier family 25 member 32Glecaprevir
go.drugbank.com/drugs/DB13879ApprovedInvestigationalIn clinical trials, this combination therapy achieved SVR12 rate, or undetectable Hepatitis C for twelve or more weeks after the end of treatment, of ≥93% across genotypes 1a, 2a, 3a, 4, 5 and 6 [L41080 … Glecaprevir is a direct acting antiviral agent and Hepatitis C virus (HCV) NS3/4A protease inhibitor that targets the the viral RNA replication.
Mixtures: MAVIRET® 100/40 MG TABLETAS RECUBIERTAS, MAVİRET 100 MG/40 MG FİLM KAPLI TABLET, 84 ADETCategories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP1A2 InhibitorsTofersen
go.drugbank.com/drugs/DB14782ApprovedInvestigational[L46108] Although there were various causes of ALS, 2% of ALS cases are due to SOD1 mutations, with more than 200 SOD1 mutations documented. … [A259028,A259033] Tofersen was granted accelerated approval from the FDA on April 25, 2023, as the first treatment for adults with ALS caused by SOD1 mutation.
Synonyms: DNA, D((2'-O-(2-METHOXYETHYL))M5RC-SP-(2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))RG-SP-(2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))RA-SP-T-SP-A-SP-M5C-SP-A-SP-T-SP-T-SP-T-SP-M5C-SP-T-SP-A-SP, -(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))RVoclosporin
go.drugbank.com/drugs/DB11693ApprovedInvestigationalWithin 10 years of being diagnosed with SLE, 5-20% of those suffering from LN develop end-stage kidney disease, a fatal condition. … [L31218] This [cyclosporine] A analog was approved by the FDA on January 22, 2021 following promising results in clinical trials.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsAmifampridine
go.drugbank.com/drugs/DB11640ApprovedAbout 50-60% of the patients develop more rapidly progressive LEMS and small cell lung cancer, which influences the prognosis [A33863]. … Patients with LEMS develop serum antibodies against presynaptic P/Q-type voltage-gated calcium channels, leading to decreased presynaptic calcium levels and reduced quantal release of acetylcholine, which
Categories: Heterocyclic Compounds, 1-RingChloride ion
go.drugbank.com/drugs/DB14547InvestigationalSynonyms: Chloride(1-)Mixtures: Telom-X-gene, VAMIN 14 IV AMINOASIT SOLÜSYONU, 500 MLBerdazimer
go.drugbank.com/drugs/DB18712ApprovedThis decision is based on positive results demonstrated in 2 Phase 3 trials, B-SIMPLE 4 and B-SIMPLE 2, where reduced lesion counts were observed with once-a-day uses of berdazimer.[L49520] … Berdazimer is a polymeric substance consisting of a polysiloxane backbone (Si-O-Si bonds) with covalently bound N-diazeniumdiolate nitric oxide (NO) donors.
Synonyms: Silsesquioxanes, 3-(2-hydroxy-1-methyl-2-nitrosohydrazinyl)propyl 3-(methylamino)propyl, polymers with silicic acid (h4sio4) tetra-et ester, hydroxy-terminated