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Debrisoquine
go.drugbank.com/drugs/DB04840ApprovedPersons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. … An adrenergic neuron-blocking drug similar in effects to guanethidine. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme.
Levopropoxyphene
go.drugbank.com/drugs/DB06793ApprovedWithdrawnLevopropoxyphene is a stereoisomer of propoxyphene in the form of 2S, 3R enantiomer. It was sold as an antitussive, but it was removed from the market in the 70s. … [T133] Levopropoxyphene was developed by Lilly and FDA approved on March 21st, 1962. This drug presented different dosages and it was administered as a capsule or suspension.
Medium-chain triglycerides
go.drugbank.com/drugs/DB13959ApprovedInvestigationalMedium-chain triglycerides (MCTs) are triglycerides made up of a glycerol backbone and three fatty acids with an aliphatic tail of six to 12 carbon atoms. … In the body, MCTs are broken down into glycerol and free fatty acids, which are directly absorbed into the blood stream and transported to the target organs to exert a range of biological and metabolic
Mecamylamine
go.drugbank.com/drugs/DB00657ApprovedInvestigationalA nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. … Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
Categories: Secondary and Tertiary AminesMolnupiravir
go.drugbank.com/drugs/DB15661Investigational[A193014] Molnupiravir was granted approval by the UK's Medicines and Health products Regulatory Agency (MHRA) on 4 November 2021 to prevent severe outcomes such as hospitalization and death due to … [A193014,A193026] With improved oral bioavailability in non-human primates, it is hydrolyzed _in vivo_, and distributes into tissues where it becomes the active 5’-triphosphate form.
Categories: Nucleic Acids, Nucleotides, and Nucleosides, Nucleosides and Nucleotides Excl. Reverse Transcriptase InhibitorsBromotheophylline
go.drugbank.com/drugs/DB14018ApprovedFrom this mixture, bromotheophylline acts as a weak diuretic that has been used along with some analgesics to relieve the symptoms of premenstrual syndrome. … Bromotheophylline is the active moiety of pamabrom, a mixture of 2-amino-2-methyl-propanol and bromotheophylline.
Mixtures: Uphamol Menstrual Tablet 500/25mg, Pain Aid PMFInfluenza A virus A/Washington/19/2020 (H1N1) antigen (MDCK cell derived, propiolactone inactivated)
go.drugbank.com/drugs/DB16727ApprovedWithdrawnVaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence against future exposure to the virus, or "antigen … Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised individuals.
Nonivamide
go.drugbank.com/drugs/DB11324ApprovedNonivamide is found in herbs and spices. It is an alkaloid from the Capsicum species. … It is naturally found in chili peppers but manufactured to produce a synthetic form for various pharmacologic preparations [L2641].
Tetrachlorodecaoxide
go.drugbank.com/drugs/DB05389ApprovedWF10 is a chlorite-based, immunomodulating drug is developed by Nuvo Research Inc. Certain preclinical evidence and clinical pilot data suggest that WF10 may be effective in treating certain cancers. … The Corporation believes the research to-date demonstrates that WF10 acts on macrophages (a type of white blood cell) by modulating the balance between inflammation and phagocytosis, a state in which the
ABBV-011
go.drugbank.com/drugs/DB18622InvestigationalABBV-011 is an antibody-drug conjugate of humanized, cysteine-engineered IgG1 monoclonal antibody targeting seizure-related 6 homolog conjugated to N-acetyl-gamma-calicheamicin.
Synonyms: an antibody-drug conjugate of humanized, cysteine-engineered IgG1 monoclonal antibody targeting seizure-related 6 homolog conjugated to N-acetyl-gamma-calicheamicin