Mecamylamine is a nicotine antagonist used to treat moderate to severe essential hypertension and uncomplicated malignant hypertension. A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier.
- Mechanism
- Curator reviewed
Mecamylamine is a ganglionic blocker which prevents stimulation of postsynaptic receptors by acetylcholine released from presynaptic nerve endings. The hypotensive effect of Mecamylamine is attributed to reduction in sympathetic tone, vasodilation, and reduced cardiac output, and is primarily postural.
- Primary indication
- For the treatment of moderately severe to severe essential hypertension and in uncomplicated cases of malignant hypertensionCurator reviewed · 3 structured indications
- Formula / weight
- C11H21N · 167.2911 g/mol (avg)
- First approval
- United States, 2006
- Brand names
Resolves to
IMYZQPCYWPFTAG-UHFFFAOYSA-NSMILESCNC1(C)C2CCC(C2)C1(C)CWhat you can answer from here — as of September 13, 2026
Which drugs share a target with Mecamylamine, and which of those have an active Phase 3 trial?
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