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Displaying results 2431 - 2440 of 10000 in total
  1. Drug

    Lerodalcibep

    go.drugbank.com/drugs/DB19071
    ApprovedInvestigational

    Lerodalcibep is a recombinant fusion protein that binds to and inhibits proprotein convertase subtilisin kexin type 9 (PCSK9). … [L54738] PCSK9 is a protein that binds to and promotes the degradation of low-density lipoprotein receptors (LDLRs), which are expressed on hepatocytes regulates circulating LDL levels.

    Categories: Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) InhibitorsSynonyms: Engineered binding protein (1-96) anti-(human proprotein convertase subtilisin/kexin type 9), derived from human tenth fibronectin type iii domain, fused via peptidyl linker (97gsgsgs102) to human serum, Protein lib003 (recombinant human proprotein convertase subtilisin/kexin type 9 ligand-binding tenth fibronectin type iii domain) fusion protein with peptide (synthetic 6-amino acid linker) fusion protein
  2. Drug

    Odronextamab

    go.drugbank.com/drugs/DB16684
    ApprovedInvestigational

    Odronextamab is a hinge-stabilized, fully human immunoglobulin G4 (IgG4)-based CD20×CD3 bispecific antibody currently evaluated for the treatment of relapsed/refractory (R/R) B-Cell non-Hodgkin lymphoma … [A254192] Odronextamab received its first approval in the European Union on August 26, 2024, for the treatment of relapsed or refractory (R/R) follicular lymphoma (FL) or R/R diffuse large B-cell lymphoma

  3. Drug

    Chlorothiazide

    go.drugbank.com/drugs/DB00880
    ApprovedInvestigationalVet approved

    A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812)

    Synonyms: 6-Chloro-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[1,2,4]thiadiazine-7-sulfonic acid amide, 6-chloro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxideCategories: Heterocyclic Compounds, 2-Ring
  4. Drug

    Clevidipine

    go.drugbank.com/drugs/DB04920
    ApprovedInvestigational

    Clevidipine is a dihydropyridine L-type calcium channel blocker that is selective for vascular smooth muscle and is indicated for blood pressure reduction when oral therapy is not an option.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Inducers
  5. Drug

    Thiocolchicoside

    go.drugbank.com/drugs/DB11582
    Investigational

    Thiocolchicoside is a semi-synthetic derivative of the colchicine, a natural anti-inflammatory glycoside which originates from the flower seeds of _Superba gloriosa_. … It is a muscle relaxant with anti-inflammatory and analgesic effects. It has potent convulsant activity and should not be administered to individuals prone to seizures.[L1663]

    Mixtures: MULTIFLEX 200/8 MG SR KAPSUL, 14 ADET, VETEXINE COMBO %1/%0.25 JEL, 50 GSynonyms: Thiocolchicine 2-glucoside analog
  6. Drug

    Tegafur-uracil

    go.drugbank.com/drugs/DB09327
    Approved

    Tegafur-uracil is an anti-tumor compound containing tegafur (1-(2-tetrahydrofuryl)-5-fluorouracil) and uracil in a molar ratio of 1:4. … [A32073] It is approved in different countries but it is not yet approved by the FDA, Health Canada or EMA.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 Substrates
  7. Drug

    Lomitapide

    go.drugbank.com/drugs/DB08827
    Approved

    Lomitapide, marketed under the brand names Juxtapid (USA) and Lojuxta (EU), is a first-in-class, small-molecule inhibitor of microsomal triglyceride transfer protein (MTP). … [A275445, A7367] This makes it a critical therapeutic option for "receptor-negative" patients who have little to no functional LDL receptor activity.

    Synonyms: 9H-FLUORENE-9-CARBOXAMIDE, N-(2,2,2-TRIFLUOROETHYL)-9-(4-(4-(((4'-(TRIFLUOROMETHYL)(1,1'-BIPHENYL)-2-YL)CARBONYL)AMINO)-1-PIPERIDINYL)BUTYL)-, N-(2,2,2-TRIFLUOROETHYL)-9-(4-(4-(((4'-(TRIFLUOROMETHYL)BIPHENYL-2-YL)CARBONYL)AMINO)PIPERIDIN-1-YL)BUTYL)-9H-FLUORENE-9-CARBOXAMIDECategories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A Inhibitors
  8. Drug

    Bambusa arundinacea stem

    go.drugbank.com/drugs/DB14588
    Investigational

    Mixtures: Re-action E
  9. Drug

    Maltodextrin

    go.drugbank.com/drugs/DB12583
    Investigational

    Mixtures: Re-action E
  10. Drug

    Toremifene

    go.drugbank.com/drugs/DB00539
    ApprovedInvestigational

    Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. … [A256923] Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs.

    Mixtures: FLOBACT - D, FLOBACT - DCategories: P-glycoprotein inhibitors, P-glycoprotein substrates