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Trifarotene
go.drugbank.com/drugs/DB12808ApprovedInvestigationalTrifarotene is a topical retinoid cream used in the treatment of acne vulgaris that was first approved for use in the United States in October 2019. … to vitamin A and are analogous only in function.
Categories: Retinoids for Topical Use in Acne, Anti-Acne Preparations for Topical UseGivosiran
go.drugbank.com/drugs/DB15066Approvedinvolved non-therapeutic measures (e.g. trigger avoidance), intravenous [hemin] for the treatment of attacks, and liver transplantation in refractory cases. … [L10202] It is manufactured by Alnylam Pharmaceuticals and was first approved for use in the United States in November 2019 for the treatment of adults with acute hepatic porphyria, a genetic disorder
Nitrous oxide
go.drugbank.com/drugs/DB06690ApprovedInvestigationalVet approvedAt room temperature, it is a colorless non-flammable gas, with a pleasant, slightly sweet odor and taste. It is used in surgery and dentistry for its anesthetic and analgesic effects. … It is known as "laughing gas" due to the euphoric effects of inhaling it, a property that has led to its recreational use as an inhalant drug.
Mixtures: Nitrous Oxide In OxygenCategories: Analgesics, Non-NarcoticClidinium
go.drugbank.com/drugs/DB00771ApprovedIt is used for the treatment of peptic ulcer disease and also to help relieve abdominal or stomach spasms or cramps due to colicky abdominal pain, diverticulitis, and irritable bowel syndrome. … Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract.
Mixtures: Nu-chlorax Capsules USPCategories: Drugs for Functional Gastrointestinal DisordersLeniolisib
go.drugbank.com/drugs/DB16217ApprovedInvestigational[A258473,A258463] Leniolisib works to inhibit hyperactive PI3Kδ.[L45753] Investigations for using leniolisib in primary Sjögren’s syndrome are ongoing.[A258468] … The FDA approved leniolisib on March 24, 2023, making it the first treatment for activated phosphoinositide 3-kinase delta syndrome (APDS).
Amisulpride
go.drugbank.com/drugs/DB06288ApprovedInvestigationalIn the US, the intravenous formulation of amisulpride is used to treat and prevent postoperative nausea and vomiting in adults, either as monotherapy or in combination with another antiemetic agent of … [A6752, L32764] Oral tablets of amisulpride is used in European countries as a treatment for acute and chronic schizophrenic disorders, as well as secondary negative symptoms in mental health disorders
Synonyms: 4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-O-anisamide, 4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamideAcalabrutinib
go.drugbank.com/drugs/DB11703ApprovedInvestigationalIt also received Orphan Drug designation, which provides incentives to assist and encourage the development of drugs for rare diseases. … or/and that fill an unmet medical need based on a surrogate endpoint.
Inavolisib
go.drugbank.com/drugs/DB15275ApprovedInvestigational[L51748,L51738] In February 2025, it was approved by Health Canada for the same indication. [L52605] … Inavolisib is an inhibitor of PI3Kα that was approved by the FDA in October 2024 for the treatment of certain patients with advanced breast cancers.
Methimazole
go.drugbank.com/drugs/DB00763ApprovedInvestigational[A184559,A184733,A184694] It was first introduced as an antithyroid agent in 1949[A184502] and is now commonly used in the management of hyperthyroidism, particularly in those for whom more aggressive … in pregnancy due to a perceived lower risk of teratogenic effects.
Tapinarof
go.drugbank.com/drugs/DB06083ApprovedInvestigationalTapinarof is a novel, first-in-class, small-molecule AhR agonist that is indicated for the treatment of adult psoriasis. … It is available as a topical cream to be applied to the affected area once daily.
Categories: Antipsoriatics for Topical Use