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Doripenem
go.drugbank.com/drugs/DB06211ApprovedWithdrawn, resulting in a premature termination of the trial. … In a clinical trial of doripenem treatment in ventilator associated pneumonia (vs. imipenem and cilastatin), it was found that doripenem carried an increased risk of death and lower clinical cure rates
Suzetrigine
go.drugbank.com/drugs/DB18927ApprovedInvestigationalSuzetrigine is a Na<sub>V</sub>1.8 voltage-gated sodium channel blocker with analgesic properties[A264948] Na<sub>V</sub>1.8 is abundantly expressed in peripheral sensory nerves to play a role in pain … [A264953] On January 30, 2025, suzetrigine was approved by the FDA as a first-in-class non-opioid analgesic.[L52098]
Prasugrel
go.drugbank.com/drugs/DB06209ApprovedInvestigationalSimilar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. … FDA approved in 2009.
Products: PRASUGREL AL 5MG HBR FTA, PRASUGREL AL 10MG HBR FTAUrea C-14
go.drugbank.com/drugs/DB09513ApprovedInvestigationalUrea 14C is a urea molecule radiolabelled with a radioactive carbon-14. … As the urease enzyme is not present in mammalian cells, the presence of urease (and the products of urea cleavage) in the stomach is evidence that H. pylori bacteria are present.
Scarlet red
go.drugbank.com/drugs/DB19136ApprovedWithdrawnScarlet red is under investigation in clinical trial NCT00591916 (New Treatment for Donor Sites).
Categories: Compounds used in a research, industrial, or household settingSynonyms: Sudan ivCarglumic acid
go.drugbank.com/drugs/DB06775ApprovedInvestigationalCarglumic acid is a drug used for the treatment of hyperammonemia in patients with a deficiency in N-acetyl glutamate synthase. … This rare genetic disorder results in elevated blood levels of ammonia, which can eventually cross the blood–brain barrier and cause neurologic problems, cerebral edema, coma, and death.
Synonyms: N-Carbamyl-L-glutamate, L-N-Carbamoylglutamic acidNelistotug
go.drugbank.com/drugs/DB19334InvestigationalNelistotug is under investigation in clinical trial NCT06062420 (A Platform Study of Novel Immunotherapy Combinations as First-line Treatment in Participants With PD-L1 Positive Recurrent/metastatic Squamous … Cell Carcinoma of the Head and Neck- GALAXIES H&N-202).
Synonyms: sapiens IGHV1-69*01 (95.9%) -(IGHD)-IGHJ1*01 (90.9%) L123>T (117), CDR-IMGT [8.8.15](26-33.51-58.97-111)) (1-122) -Homo sapiens IGHG1*01 (100%), G1m17,1 CH1 K120, CH3 D12, L14 (CH1 K120 (219) (123-220), hiBenzoin resin
go.drugbank.com/drugs/DB11222ApprovedWhile benzoin resin is used as a common ingredient in incense-making and perfumery, it is also used clinically as a mild antiseptic agent in over-the-counter products to clean sores, cuts, wounds, and … Benzoin resin is a balsamic resin obtained from the bark of several species of trees in the genus _Styrax_.
Mixtures: Skin-E-dip Ont, Blistex Kank-AHuman cytomegalovirus immune globulin
go.drugbank.com/drugs/DB13886ApprovedInvestigationalCytomegalovirus (CMV) may lead to a wide spectrum of infection in immunocompetent hosts. … As a consequence, CMV disease is restricted to the immunocompromised or immunologically immature host, in which it can lead the devastating result of transplant rejection [A32498], [L2229].
Cobicistat
go.drugbank.com/drugs/DB09065ApprovedInvestigationalMore specifically, cobicistat is indicated to increase systemic exposure of atazanavir or darunavir (once daily dosing regimen) in combination with other antiretroviral agents in the treatment of HIV-1 … Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic exposure of coadministered
Categories: Antivirals used in combination for the treatment of HIV infections