Identification

Summary

Benzoin resin is a compound used to protect small wounds or canker sores.

Generic Name
Benzoin resin
DrugBank Accession Number
DB11222
Background

Benzoin resin is a balsamic resin obtained from the bark of several species of trees in the genus Styrax. There are two common kinds of benzoin, benzoin Siam and benzoin Sumatra, that are obtained from different species of the Styrax tree. While benzoin resin is used as a common ingredient in incense-making and perfumery, it is also used clinically as a mild antiseptic agent in over-the-counter products to clean sores, cuts, wounds, and skin abrasions as tincture of benzoin, or benzoin in a solution of alcohol. Tincture of benzoin solution is a topical adhesive agent used to provide tackiness and enhance the adhesive property of tape.

Type
Biotech
Groups
Approved
Synonyms
  • Benzoin absolute
  • Benzoin resin, unspecified
  • Benzoin tincture, compound
  • Gum benzoin
  • Gum benzoin tincture
  • Gum sumatra
External IDs
  • FEMA No. 2133

Pharmacology

Indication

Indicated for mild antisepsis of skin, cuts, and abrasions.

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Benzoin resin exhibits antiseptic properties.

Mechanism of action

The full mechanism of action is not yet fully established. Benzoic acid present in tincture of benzoin as well as the strong alcoholic content of the common pharmaceutical preparation are thought to play antiseptic and dehydrating effects on the oedematous tissue 1. Benzoin resin is thought to form a fine coating under the adhesive tapes and over skin, abrasions, wounds, and oral lesions when used as a topical adhesive agent. Antiseptic preparation maintains skin integrity and protects the skin from adhesive ingredients and body fluids.

Absorption

No pharmacokinetic data available.

Volume of distribution

No pharmacokinetic data available.

Protein binding

No pharmacokinetic data available.

Metabolism

No pharmacokinetic data available.

Route of elimination

No pharmacokinetic data available.

Half-life

No pharmacokinetic data available.

Clearance

No pharmacokinetic data available.

Adverse Effects
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Toxicity

No toxicokinetic data available.

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

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Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Benz ProtectLiquid100 mg/1mLTopicalGeritrex Llc2015-07-31Not applicableUS flag
Benzoin Compound TinctureLiquid100 mg/1mLTopicalGeritrex Llc2015-07-31Not applicableUS flag
Benzoin Compound TinctureLiquid1000 mg/1mLTopicalHumco Holding Group, Inc.2008-01-01Not applicableUS flag
Benzoin Compound Tincture Professional PackLiquid1000 mg/1mLTopicalHumco Holding Group, Inc.1998-03-252020-09-30US flag
Benzoin TinctureLiquid1000 mg/1mLTopicalPharma Nobis, LLC2008-01-01Not applicableUS flag
Benzoin TinctureLiquid1000 mg/1mLTopicalHumco Holding Group, Inc.2008-01-01Not applicableUS flag
Benzoin TinctureLiquid1000 mg/1mLTopicalHumco Holding Group, Inc.2008-01-01Not applicableUS flag
Benzoinspray - Aer 25%Aerosol25 %TopicalPharmascience Inc1997-09-292016-10-28Canada flag
Compound BenzoinTincture100 mg/1mLTopicalPaddock Laboratories, LLC2014-04-022018-11-09US flag
Compound Benzoin TinctureLiquid10 g/100mLTopicalMedical Chemical Corporation1954-06-15Not applicableUS flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
BenzoinBenzoin resin (0.6 g/0.6mL) + Aloe vera leaf (.12 g/0.6mL) + Liquidambar styraciflua resin (.48 g/0.6mL) + Tolu balsam (.24 g/0.6mL)SwabTopicalJames Alexander Corporation1976-10-252025-02-28US flag
Blistex Kank-ABenzoin resin (0.5 g/100mL) + Benzocaine (20 g/100mL)LiquidBuccalBlistex Inc.2011-12-01Not applicableUS flag
Chase ColdsorexBenzoin resin (12.46 %) + Camphor (3 %) + Levomenthol (0.62 %) + Myrrh (5 %)LiquidTopicalStella Pharmaceutical Canada Inc.1997-09-042003-11-20Canada flag
Cold Sore LotionBenzoin resin (2.505 g / 100 mL) + Benzocaine (2 g / 100 mL) + Camphor (10 g / 100 mL) + Levomenthol (200 mg / 100 mL) + Myrrh (3.84 g / 100 mL)LotionTopicalD.C. Labs Limited1966-12-312003-07-11Canada flag
Cold Sore LotionBenzoin resin (94 %) + Camphor (4 %) + Levomenthol (2 %)LotionTopicalStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1982-12-312002-07-31Canada flag
Compound Benzoin TinctureBenzoin resin (10 %) + Aloe vera leaf (2 %) + Balsam of Peru (4 %) + Ethanol (76 %) + Liquidambar styraciflua resin (8 %)LiquidTopicalAcme United Corporation1977-12-311997-05-30Canada flag
Compound Benzoin Tincture USPBenzoin resin (10 %) + Ethanol (77 %)TinctureTopicalMedi Flex Inc.1998-08-312002-06-26Canada flag
Friar's BalsamBenzoin resin (10 g / 100 mL) + Aloe vera leaf (2 g / 100 mL) + Balsam of Peru (4 g / 100 mL) + Liquidambar styraciflua resin (8 g / 100 mL)LiquidRespiratory (inhalation)Lawton's Drug Stores Ltd.1987-12-311997-04-02Canada flag
Friar's BalsamBenzoin resin (100 mg / mL) + Aloe vera leaf (20 mg / mL) + Balsam of Peru (40 mg / mL) + Liquidambar styraciflua resin (80 mg / mL)LiquidRespiratory (inhalation)D.C. Labs Limited2001-11-272003-07-11Canada flag
Friar's Balsam Benzoin TinctureBenzoin resin (10 g / 100 mL) + Aloe vera leaf (2 g / 100 mL) + Balsam of Peru (4 g / 100 mL) + Liquidambar styraciflua resin (8 g / 100 mL)TinctureRespiratory (inhalation); TopicalTEVA Canada Limited1982-12-312021-07-29Canada flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
BenzoinBenzoin resin (0.6 g/0.6mL) + Aloe vera leaf (.12 g/0.6mL) + Liquidambar styraciflua resin (.48 g/0.6mL) + Tolu balsam (.24 g/0.6mL)SwabTopicalJames Alexander Corporation1976-10-252025-02-28US flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
GK21SBA74R
CAS number
9000-05-9

References

General References
  1. PERLMAN HH: Compound benzoin tincture in treatment of vesiculobullous lesions of mucous membranes. Arch Derm Syphilol. 1950 Jan;61(1):119-21. [Article]
PubChem Substance
347911157
RxNav
1406
Wikipedia
Benzoin_(resin)
MSDS
Download (67.2 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
LiquidTopical100 mg/1mL
SwabTopical
LiquidTopical1000 mg/1mL
AerosolTopical25 %
LiquidBuccal
LotionTopical
TinctureTopical100 mg/1mL
LiquidTopical10 g/100mL
TinctureTopical
TinctureTopical10 %
TinctureRespiratory (inhalation); Topical
LiquidNasal; Respiratory (inhalation)
LiquidRespiratory (inhalation)
LiquidTopical
StickTopical
Solution
OintmentTopical
AerosolTopical
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)60MSDS
water solubilityInsolubleMSDS

Drug created at December 03, 2015 16:51 / Updated at December 04, 2022 18:48