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Rutin
go.drugbank.com/drugs/DB01698ApprovedInvestigationalA flavonol glycoside found in many plants, including buckwheat; tobacco; forsythia; hydrangea; viola, etc. It has been used therapeutically to decrease capillary fragility.
Synonyms: 3-[[6-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-oneMixtures: Rose Hips 500plus Nu Life, Nutriforte Non-Acidic Vitamin C 1000 mg with BioflavonoidsAprocitentan
go.drugbank.com/drugs/DB15059ApprovedInvestigationalApproximately 10-15% of patients with hypertension have resistant hypertension, defined as uncontrolled high blood pressure despite the combined use of a renin-angiotensin system blocker, a calcium channel … blocker, and a diuretic at maximally tolerated doses.
Categories: Cytochrome P-450 CYP2C18 Inhibitors, Cytochrome P-450 CYP3A InducersSomatrem
go.drugbank.com/drugs/DB09098ApprovedWithdrawnthese hormone agents have been proven effective at increasing the height of children with or without growth hormone deficiency [A32292]. … Such discussion revolves around whether patients' natural disposition of short stature should be considered a medical condition justifying medical treatment with such hormone therapy - especially when
Mixtures: Protropin Pws 5mg/vial, Protropin - Kit Im Sc 5mg/vialAlbutrepenonacog alfa
go.drugbank.com/drugs/DB13884ApprovedIt is currently marketed in the forms of 250, 500, 1000 and 2000 IU/vial.[L2305] … Albutrepenonacog alfa (rIX-RFP) is a recombinant fusion protein that links a recombinant coagulation factor IX (rFIX) with a recombinant human albumin (rAlbumin).
Products: IDELVION 250 IU powder and solvent for solution for injection, IDELVION 500 IU powder and solvent for solution for injectionMevastatin
go.drugbank.com/drugs/DB06693ExperimentalMevastatin is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself. … Two years later, the research group isolated a compound structurally similar to hydroxymethylglutarate (HMG) that inhibited the incorporation of acetate.
Regadenoson
go.drugbank.com/drugs/DB06213ApprovedInvestigationalRegadenoson is an A2A adenosine receptor agonist that causes coronary vasodilation and used for myocardial perfusion imagining. Manufactured by Astellas and FDA approved April 10, 2008.
Categories: Adenosine A receptor agonists, Adenosine A2 Receptor AgonistsTocopherol
go.drugbank.com/drugs/DB11251ApprovedInvestigationalTocopherol, as a group, is composed of soluble phenolic compounds that consist of a chromanol ring and a 16-carbon phytyl chain. … Tocopherols can be found in the diet as part of vegetable oil such as corn, soybean, sesame, and cottonseed.
Mixtures: Protect Cardio AF, Vital-D RxCategories: Compounds used in a research, industrial, or household setting, Cytochrome P-450 SubstratesAC-100
go.drugbank.com/drugs/DB05671InvestigationalAC-100 is a novel synthetic peptide derived from an endogenous human protein produced by bone and dental cells (a fragment from matrix extracellular phosphoglycoprotein).
Rindopepimut
go.drugbank.com/drugs/DB05374InvestigationalRindopepimut (CDX-110) is an injectable peptide cancer vaccine which targets a mutant protein called EGFRvIII present in about 25% to 30% of glioblastoma cases. … The vaccine consists of the EGFRv3-specific peptide (a 13-amino acid mutant vIII epitope) conjugated to the non-specific immunomodulator keyhole limpet hemocyanin (KLH).
Stiripentol
go.drugbank.com/drugs/DB09118ApprovedInvestigational[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzymes. … Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.
Categories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 Substrates