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Chymopapain
go.drugbank.com/drugs/DB06752ApprovedWithdrawnChymopapain was first isolated in 1941 from the crude latex derived from the fruit of Carica papaya by squeezing the green papaya while on the plant prior to harvest. … [L2482]It is an extracellular plant cysteine proteinase similar to papain in specificity.[A32688] Chymopapain was developed by Chart Medcl and FDA approved on November 10, 1982.
Categories: Enzymes and CoenzymesAminophenazone
go.drugbank.com/drugs/DB01424ApprovedWithdrawnAminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic properties that carries a risk of agranulocytosis.
Donanemab
go.drugbank.com/drugs/DB16647ApprovedInvestigational[L50988] It works to reduce amyloid beta plaques and impede the progression of AD.[L50988] … [A232214] On July 2, 2024, donanemab was approved by the FDA for the treatment of AD in patients with mild cognitive impairment or dementia symptoms.
Categories: Amino Acids, Peptides, and ProteinsMiltefosine
go.drugbank.com/drugs/DB09031ApprovedInvestigationalIt can be administered topically or orally and is only indicated in patients aged 12 years or older. … It is currently the only recognized oral agent used to treat visceral, cutaneous, and mucosal forms of leishmaniasis, a neglected tropical disease.
Categories: Agents Against Leishmaniasis and Trypanosomiasis, Antiparasitic Products, Insecticides and RepellentsHydroflumethiazide
go.drugbank.com/drugs/DB00774ApprovedWithdrawnA thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822)
Categories: hydroflumethiazide and potassium, Genito Urinary System and Sex HormonesProlyl 3-hydroxylase 1
go.drugbank.com/bio_entities/BE0002202TargetEnzymeHumansHas prolyl 3-hydroxylase activity and catalyzes the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in pro-collagen chains, a critical step for the formation of mature collagen
Synonyms: Leucine- and proline-enriched proteoglycan 1Alginic acid
go.drugbank.com/drugs/DB13518ApprovedInvestigationalWithdrawnAlginic acid, also referred to as algin or alginate, is a hydrophilic or anionic polysaccharide isolated from certain brown seaweed (_Phacophycae_) via alkaline extraction. … It is also available in oral dietary supplements and is found in antacids such as Gaviscon to inhibit gastroesophageal reflux by creating a physical barrier in presence of gastric acid [F46].
Mixtures: Zinc and Algin Tab Nu Life, MILACID® SACHET POR 10ML SABOR MENTACategories: Alimentary Tract and Metabolism, Drugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord)Mavorixafor
go.drugbank.com/drugs/DB05501ApprovedInvestigationalby a reduced number of mature neutrophils and lymphocytes. … [L50642] It was first approved by the FDA on April 30, 2024, for the treatment of warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome, a genetic immunodeficiency disorder characterized
Categories: Antineoplastic and Immunomodulating AgentsEpcoritamab
go.drugbank.com/drugs/DB16672ApprovedInvestigationalAlthough this regimen is effective in up to 60% of patients, patients with relapsed or refractory DLBCL have poor outcomes. … [A259736,A258488,A259761,L46516] Epcoritamab promotes the activation and expansion of T-cells and, by being able to bind to both CD20 and CD3, it leads to the T-cell–mediated killing of CD20+ malignant
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsMilbemycin oxime
go.drugbank.com/drugs/DB11531ExperimentalVet approvedMixtures: Nexgard Spectra 75mg/15mg Chewable Tablets for Dogs >15-30kg, Nexgard Spectra 150mg/30mg Chewable Tablets for Dogs >30-60kg