Prolyl 3-hydroxylase 1

BE0002202ProteinHumansP3H1

Has prolyl 3-hydroxylase activity and catalyzes the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in pro-collagen chains, a critical step for the formation of mature collagen trimers (PubMed:39245686). It is acted on by 3 drugs in DrugBank.

Gene name
P3H1
UniProtKB entry
Q32P28Swiss-Prot
Cellular location
Endoplasmic reticulum
Residues / weight
736 residues · 83,393 Da
Also known as
1.14.11.7 · GROS1 · Growth suppressor 1 · LEPRE1 · Leprecan-1

Resolves to

Protein
UniProtQ32P28UniProt nameP3H1_HUMAN
Gene
HGNCHGNC:19316NCBI Gene64175GenBank11127636GeneCardsP3H1
Pharmacology
KEGGhsa:64175
Structure
PDB8K0EPDB8K0FPDB8K0I
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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15GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Prolyl 3-hydroxylase 1, how selective are they, and which programs against it are still in active trials?

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