Aminophenazone

DB01424ApprovedWithdrawnSmall molecule

Aminophenazone is an analgesic drug used to treat acute migraine attacks in combination with ergotamine and caffeine. Aminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic properties that carries a risk of agranulocytosis.

Chemical structure of Aminophenazone
Mechanism
Curator reviewed
Primary indication
Formerly widely used as an antipyretic and analgesic in rheumatism, neuritis, and common colds.Curator reviewed · 1 structured indication
Formula / weight
C13H17N3O · 231.2936 g/mol (avg)
Also known as
(Dimethylamino)phenazone · 4-Dimethylaminoantipyrine · 4-Dimethylaminophenazone · Aminofenazone · Aminopyrine
Code names
NSC-4993

Resolves to

Compound
UNII01704YP3MOCAS58-15-1ChEMBLCHEMBL288470ChEBI160246PubChem6009KEGGD00556
Clinical / RWD
RxNorm695ATCN02BB03ATCN02BB53ATCN02BB73PharmGKBPA164748135
Structure
InChIKeyRMMXTBMQSGEXHJ-UHFFFAOYSA-NSMILESCN(C)C1=C(C)N(C)N(C1=O)C1=CC=CC=C1
Targets
P23219PTGS1
Transporters
Q4U2R8SLC22A6

What you can answer from here — as of September 23, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action
Listed above
1TransporterSubstrate / inhibitor direction, not just membership
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1,847Drug interactionsStructured to mechanism, not free text
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3Clinical trialsPhase, status and sponsor resolved per trial
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1Structured indicationCondition, population, route and combination as fields, not prose
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17ContraindicationsEach with its own population and attribute set
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3Marketed productsAcross 2 countries and 2 labellers
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3ATC codesIncluding every combination product, plus 22 drug categories
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28+ReferencesStructured and connected to the statements they support
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