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Displaying results 2491 - 2500 of 2828 in total
  1. Drug

    Levcromakalim

    go.drugbank.com/drugs/DB21154
    Investigational

    The usage of the INN stem '-kalim' in the name indicates that Levcromakalim is a potassium channel activator, antihypertensive.

  2. Drug

    Velufenacin

    go.drugbank.com/drugs/DB21473
    Investigational

    The usage of the INN stem '-fenacin' in the name indicates that Velufenacin is a muscarinic receptor antagonist.

  3. Drug

    Lepzacitinib

    go.drugbank.com/drugs/DB21646
    Investigational

    The usage of the INN stem '-citinib' in the name indicates that Lepzacitinib is a Janus kinase inhibitor.

  4. Drug

    Luvometinib

    go.drugbank.com/drugs/DB21696
    Investigational

    The usage of the INN stem '-tinib' in the name indicates that Luvometinib is a tyrosine kinase inhibitor.

  5. Drug

    Pebezertinib

    go.drugbank.com/drugs/DB21705
    Investigational

    The usage of the INN stem '-ertinib' in the name indicates that Pebezertinib is a epidermal growth factor receptor (EGFR) inhibitor.

  6. Drug

    Inlexisertib

    go.drugbank.com/drugs/DB21713
    Investigational

    The usage of the INN stem '-sertib' in the name indicates that Inlexisertib is a serine/threonine kinase inhibitor.

  7. Target

    Cyclin-dependent kinase 8

    go.drugbank.com/bio_entities/BE0002224
    TargetHumans

    Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression (PubMed:10993082). … Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes.

    Synonyms: Mediator complex subunit CDK8
  8. Target

    Proteasome subunit alpha type-4

    go.drugbank.com/bio_entities/BE0003913
    TargetHumans

    Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. … This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)

    Synonyms: Multicatalytic endopeptidase complex subunit C9
  9. Target

    Atypical kinase COQ8A, mitochondrial

    go.drugbank.com/bio_entities/BE0009381
    TargetHumans

    Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:21296186, PubMed:25498144, PubMed

    Synonyms: Chaperone activity of bc1 complex-like
  10. Drug

    Promestriene

    go.drugbank.com/drugs/DB12487
    Investigational

    Promestriene (3-propyl ethyl, 17B-methyl estradiol) has been used in trials studying the prevention of Hypospadias. It is a synthetic estrogen analog, which is used in topical estrogen therapy. Promestriene’s potential for treating vagin...

    Categories: Genito Urinary System and Sex Hormones, Sex Hormones and Modulators of the Genital System