Proteasome subunit alpha type-4

BE0003913ProteinHumansPSMA4

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. It is acted on by 1 drug in DrugBank.

Gene name
PSMA4
UniProtKB entry
P25789Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
261 residues · 29,484 Da
Also known as
alpha-3 · HC9 · Macropain subunit C9 · Multicatalytic endopeptidase complex subunit C9 · Proteasome component C9

Resolves to

Protein
UniProtP25789UniProt namePSA4_HUMAN
Gene
HGNCHGNC:9533NCBI Gene5685GenBank220030GeneCardsPSMA4
Pharmacology
KEGGhsa:5685
Structure
PDB4R3OPDB4R67PDB5A0Q
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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28GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Proteasome subunit alpha type-4, and which indications are they being tested in?

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