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Acamprosate
go.drugbank.com/drugs/DB00659ApprovedInvestigationalAlcohol use disorder is responsible for a large worldwide burden of morbidity, premature mortality, and economic consequences resulting from accidents, violence, incarceration, decreased productivity, … It was first approved by the FDA in 2004 and initially marketed by Forest Laboratories.[L31783]
Peppermint oil
go.drugbank.com/drugs/DB11198ApprovedInvestigationalExtracted from the stem, leaves, and flowers of _Mentha piperita_ L. plant, peppermint oil (Mentha piperita) is a popular essential oil used in aromatherapy for both external and internal use. … Due to its effectiveness in relaxing GI smooth muscle but ability to induce gastroesophageal reflux, enteric-coated formulations of peppermint oil has been established which bypass the upper GI tract unmetabolized
Categories: Alimentary Tract and Metabolism, Herbs and Natural ProductsWart Viral
go.drugbank.com/conditions/DBCOND0140696Drugs: DiphencyproneSynonyms: Viral wart of skin and/or mucous membrane caused by human papillomavirus, Viral wart of skin and/or mucous membrane caused by human papillomavirus (disorder)Pediculosis Capitis
go.drugbank.com/conditions/DBCOND0043220Drugs: LindaneSynonyms: Pediculosis and other liceFosphenytoin
go.drugbank.com/drugs/DB01320ApprovedInvestigationalIts main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repetitive firing of action potentials. … It works by slowing down impulses in the brain that cause seizures.
Categories: Phenytoin and ProdrugsDexrazoxane
go.drugbank.com/drugs/DB00380ApprovedInvestigationalWithdrawn[PubChem] The Food and Drug Administration has designated dexrazoxane as an orphan drug for use in the prevention or reduction in the incidence and severity of anthracycline-induced cardiomyopathy. … An antimitotic agent with immunosuppressive properties. Dexrazoxane, the (+)-enantiomorph of razoxane, provides cardioprotection against anthracycline toxicity.
Lonafarnib
go.drugbank.com/drugs/DB06448ApprovedInvestigational[A224379, A224384, A224389, A224394, A224399] Mechanistically, HGPS is underpinned by a single heterozygous C-to-T mutation at position 1824 of the _LMNA_ gene, which results in the accumulation of an … aberrant farnesylated form of lamin A called progerin in the inner nuclear membrane.
Categories: Alimentary Tract and Metabolism, Various Alimentary Tract and Metabolism ProductsFexinidazole
go.drugbank.com/drugs/DB12265Approved[A237555, A237560] Fexinidazole received a positive opinion from the European Medicines Agency (EMA) in November 2018 and was approved by the FDA on July 16, 2021. … all-oral treatment for first and second stage HAT caused by _T. brucei gambiense_.
Categories: Agents Against Leishmaniasis and Trypanosomiasis, Antiparasitic Products, Insecticides and RepellentsFitusiran
go.drugbank.com/drugs/DB15002ApprovedInvestigational[L52865] By causing the degradation of antithrombin mRNA and promoting thrombin generation, fitusiran works to restore hemostasis in patients with hemophilia.[A273770] … Fitusiran is an antithrombin-directed double-stranded small interfering ribonucleic acid (siRNA) that is covalently linked to a ligand containing a triantennary N-acetylgalactosamine (GalNAc) moiety.
Categories: Nucleic Acids, Nucleotides, and NucleosidesAdemetionine
go.drugbank.com/drugs/DB00118ApprovedInvestigationalNutraceuticalIt possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed) … Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms.
Categories: Amino Acids and Derivatives, Alimentary Tract and Metabolism