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Evinacumab
go.drugbank.com/drugs/DB15354ApprovedInvestigationalcardiovascular risk, and it was these observations that provided a rationale for the development of a therapy targeted against ANGPTL3. … [A229273] Loss-of-function mutations in _ANGPTL3_ have been noted to result in hypolipidemia and subsequent reductions in cardiovascular risk, whereas increases in function appear to be associated with
LI-301
go.drugbank.com/drugs/DB05509ExperimentalIt has a novel mode of action combining both the light effect of a Selective Serotonin Reuptake Inhibitor ("SSRI")(most likely antagonistic at 5HT1a receptors) and antagonism at mu-opioid receptors. … LI 301 is an orally bio-available compound delivered in a fast melt mechanism with taste masking enabling it to be taken anytime without water.
Piperonyl butoxide
go.drugbank.com/drugs/DB09350ApprovedVet approvedIt is used for the treatment of head, pubic (crab), and body lice. Piperonyl butoxide is a synergist. … It has no pesticidal activity of its own, but acts to increase the activity of pesticides such as carbamates, pyrethrins, pyrethroids, and rotenone.
Mixtures: El piojito Lice Killing, KWELL-P %0,3 + %3 MEDİKAL ŞAMPUAN, 120 MLInebilizumab
go.drugbank.com/drugs/DB12530ApprovedInvestigational[A214280, A214289, A214292, A214295, A214298, A214301] Inebilizumab was granted initially FDA approval on June 11, 2020, for the treatment of anti-aquaporin 4 positive NMOSD patients. … [L14315] Given its mechanism of action and good safety profile, it may prove useful in the treatment of other conditions linked to autoimmune antibody production or B-cell malignancies.
UCB7362
go.drugbank.com/drugs/DB17096ExperimentalIt has shown high potency in biochemical (IC<sub>50</sub> = 7 nM), _in vitro_ (_P. falciparum_ 3D7 lactate dehydrogenase growth inhibition assay IC<sub>50</sub> = 10 nM), and _in vivo_ (50 mg/kg dose … [A254222] Plasmepsins are aspartyl proteases produced by the malaria parasite _Plasmodium falciparum_, and PMX is considered to be essential for parasite egress and invasion.
Benzoic acid
go.drugbank.com/drugs/DB03793ApprovedInvestigationalIt is conjugated to GLYCINE in the liver and excreted as hippuric acid. … Recent research shows that sodium benzoate may be beneficial as an add-on therapy (1 gram/day) in schizophrenia. Total Positive and Negative Syndrome Scale scores dropped by 21% compared to placebo.
Mixtures: ARTU 100 ML SURUP, SKINOREN %20 KREM, 30 GAmmonium chloride
go.drugbank.com/drugs/DB06767ApprovedInvestigationalVet approvedIt is highly soluble in water producing mildly acidic solutions.
Mixtures: SELDIYET GRANUL, 100 GR, FENIDIN EKSPEKTORAN SURUP, 150 MLTislelizumab
go.drugbank.com/drugs/DB14922ApprovedInvestigational[A262909] By blocking PD-L1/PD-L2–mediated cell signaling, tislelizumab restores T-cell function through cytokine production, resulting in immune-mediated antitumor responses. … [L50346] It has subsequently been approved for additional cancers in the US and EU. [L49349]
Categories: PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitorsAbaloparatide
go.drugbank.com/drugs/DB05084ApprovedInvestigational[L740] In October 2022, the EMA's Committee for Medicinal Products for Human Use (CHMP) recommended abaloparatide be granted marketing authorization in Europe [L43552] and the drug was fully authorized … [L740] It is a synthetic 34 amino acid peptide with 41% homology to human parathyroid hormone 1-34 and human PTHrP 1-34.
CIGB 300
go.drugbank.com/drugs/DB16464InvestigationalCIGB-300, is under investigation in clinical trials for its potential to treat various conditions, including NCT01639638 (recurrent and nonrecurrent condyloma) and NCT01639625 (squamous cell carcinoma