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Tazemetostat
go.drugbank.com/drugs/DB12887ApprovedInvestigational[L11476] Tazemetostat was first named in literature as EPZ-6438.[A190363] Tazemetaostat was granted FDA approval on 23 January 2020.[L11476]
Aggrecan core protein
go.drugbank.com/bio_entities/BE0004104TargetHumansThis proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region
Polypeptides: Aggrecan core proteinSynonyms: Cartilage-specific proteoglycan core protein, Chondroitin sulfate proteoglycan core protein 1Mequinol
go.drugbank.com/drugs/DB09516ApprovedWithdrawnIt is found as an active ingredient in topical drugs used for skin depigmentation indicated for the treatment of solar lentigines. … Mequinol is a phenol used in various applications.
Categories: Compounds used in a research, industrial, or household setting, Skin Lightening AgentTofersen
go.drugbank.com/drugs/DB14782ApprovedInvestigational[L46108] Although there were various causes of ALS, 2% of ALS cases are due to SOD1 mutations, with more than 200 SOD1 mutations documented. … [L52735] Tofersen demonstrated efficacy in reducing the concentration of SOD1 in CSF and of neurofilament light chains in plasma over 28 weeks, although the ALS Functional Rating Scale–Revised did not
Synonyms: DNA, D((2'-O-(2-METHOXYETHYL))M5RC-SP-(2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))RG-SP-(2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))RA-SP-T-SP-A-SP-M5C-SP-A-SP-T-SP-T-SP-T-SP-M5C-SP-T-SP-A-SPPhenol
go.drugbank.com/drugs/DB03255ApprovedInvestigationalPhenol has been used to disinfect skin and to relieve itching. Phenol is also used as an oral analgesic or anesthetic in products such as Chloraseptic to treat pharyngitis. … Additionally, phenol and its related compounds are used in surgical ingrown toenail treatment, a process termed phenolization.
Mixtures: Au Kah Chuen Skin Lotion, DİŞİNOL 2 G + 0,5 G + 3,5 G/10 ML ÇÖZELTİCategories: Compounds used in a research, industrial, or household settingConivaptan
go.drugbank.com/drugs/DB00872ApprovedIt was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH).
Products: Vaprisol Dextrose In Plastic ContainerTosedostat
go.drugbank.com/drugs/DB11781InvestigationalTosedostat is an inhibitor of the M1 family of aminopeptidases, in particular PuSA, and LTA4 hydrolase. … It has demonstrated anti-tumour activity in a number of models of cancer, both as a single agent and in synergy with cytotoxic agents such as carboplatin and paclitaxel.
Hydroxyethyl cellulose
go.drugbank.com/drugs/DB11602ApprovedIt is often used as an ingredient in ophthalmic pharmaceutical preparations such as artificial tear solutions and adjunct agent in topical drug formulations to facilitate the delivery of drugs with hydrophobic … It is used as a key ingredient in many household cleaning products, lubricants and cosmetics due to its non-ionic and water-soluble nature.
Salts: Hydroxyethyl cellulose (2000 MPa.s at 1%), Hydroxyethyl cellulose (280 MPa.s at 2%)Categories: Compounds used in a research, industrial, or household settingSparsentan
go.drugbank.com/drugs/DB12548ApprovedInvestigational[L45300,L45315] In September 2024, it was granted full approval for an expanded indication. … [A257330,L45300] Sparsentan is first in its class and orally active, and was created by merging the structural elements of [irbesartan], an AT<sub>1</sub>R antagonist, and biphenylsulfonamide, an ET<sub
Categories: Agents Acting on the Renin-Angiotensin SystemAbametapir
go.drugbank.com/drugs/DB11932Approved[A216178] Abametapir was first approved for use in the United States under the brand name Xeglyze on July 27, 2020.[L15163] … The improved ovicidal activity (90-100% _in vitro_) of abemetapir allows for a single administration, in contrast to many other topical treatments, and its novel and relatively non-specific mechanism may