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Displaying results 2571 - 2580 of 10000 in total
  1. Drug

    Etoricoxib

    go.drugbank.com/drugs/DB01628
    ApprovedInvestigationalWithdrawn

    Etoricoxib is a new COX-2 selective inhibitor. … Like any other COX-2 selective inhibitor, Etoricoxib selectively inhibits isoform 2 of cyclo-oxigenase enzyme (COX-2) to reduce the generation of prostaglandins (PGs) from arachidonic acid.

    Categories: COX-2 Inhibitors, Selective Cyclooxygenase 2 Inhibitors (NSAIDs)Synonyms: 5-chloro-2-(6-methylpyridin-3-yl)-3-(4-(methylsulfonyl)phenyl)pyridine, 5-Chloro-3-(4-methanesulfonyl-phenyl)-6'-methyl-[2,3']bipyridinyl
  2. Drug

    CM4620

    go.drugbank.com/drugs/DB16466
    Investigational

    CM4620 (Zegocractin), is under investigation in multiple clinical trials, including NCT04195347 (pancreatitis due to asparaginase), NCT03709342 (PK/PD study in acute pancreatitis), NCT03401190 and NCT04681066 (pancreatitis and SIRS), and...

    Synonyms: BENZAMIDE, N-(5-(6-CHLORO-2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)-2-PYRAZINYL)-2-FLUORO-6-METHYL-, N-(5-(6-CHLORO-2,2-DIFLUOROBENZO(D)(1,3)DIOXOL-5-YL)PYRAZIN-2-YL)-2-FLUORO-6-METHYLBENZAMIDECategories: Heterocyclic Compounds, 1-Ring
  3. Drug

    ZM-39923

    go.drugbank.com/drugs/DB17064
    Experimental

    ZM-39923 is a small molecule that inhibits Janus kinase and human tissue transglutaminase (TGM2).[A253177]

    Synonyms: 3-(benzyl(propan-2-yl)amino)-1-(naphthalen-2-yl)propan-1-one, 1-propanone, 3-((1-methylethyl)(phenylmethyl)amino)-1-(2-naphthalenyl)-
  4. Drug

    Deoxyinosine

    go.drugbank.com/drugs/DB02380
    Experimental

    Synonyms: 2'-deoxyinosine, 9-(2-deoxy-β-D-erythro-pentofuranosyl)-9H-purin-6-olCategories: Heterocyclic Compounds, 2-Ring
  5. Drug

    Cannabidivarin

    go.drugbank.com/drugs/DB14050
    Investigational

    CBDV has also been shown to inhibit the activity of diacylglycerol (DAG) lipase-α, the primary enzyme responsible for the synthesis of the endocannabinoid, 2-arachidonoylglycerol (2-AG) [A33296, A33347 … While the primary components of cannabis, CBD and THC, have been shown to modulate many of their physiological effects through their binding to the cannabinoid-1 (CB1R) and cannabinoid-2 (CB2R) receptors

    Synonyms: 2-[(1R,6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]-5-propylbenzene-1,3-diol, CBD-V
  6. Drug

    HEPES

    go.drugbank.com/drugs/DB16872
    Investigational

    Synonyms: 4-(2-Hydroxyethyl)-1-piperazineethane sulfonic acid, 4-(2-Hydroxyethyl)-1-piperazineethane sulphonic acidCategories: Heterocyclic Compounds, 1-Ring, Compounds used in a research, industrial, or household setting
  7. Drug

    PI-103

    go.drugbank.com/drugs/DB17046
    Experimental

    PI-103 is an inhibitor of p110α of class I PI3K.[A253092]

    Categories: Heterocyclic Compounds, 1-RingSynonyms: Phenol, 3-(4-(4-morpholinyl)pyrido(3',2':4,5)furo(3,2-d)pyrimidin-2-yl)-
  8. Drug

    SUN-101

    go.drugbank.com/drugs/DB17238
    Investigational

    Synonyms: (2R)-4-(ethylamino)-1-[4-[[(2R)-4-(ethylamino)-2-hydroxybutyl]amino]butylamino]butan-2-ol
  9. Drug

    ABX-002

    go.drugbank.com/drugs/DB18157
    Investigational

    Synonyms: 2-(3,5-DICHLORO-4-((4-HYDROXY-3-(PROPAN-2-YL)PHENYL)METHYL)PHENOXY)-N-METHYLACETAMIDE
  10. Drug

    vCP2292

    go.drugbank.com/drugs/DB19292
    Investigational

    vCP2292 is under investigation in clinical trial NCT01982487 (Vaccine Therapy and IDO1 Inhibitor INCB024360 in Treating Patients With Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Who Are in Remission).

    Synonyms: ALVAC (2)-NY-ESO-1(M)-TRICOM, ALVAC(2)-NY-ESO-1 (M)/TRICOM vaccine