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Displaying results 2591 - 2600 of 10000 in total
  1. Target

    Camphor 5-monooxygenase

    go.drugbank.com/bio_entities/BE0001246
    TargetPseudomonas putida

    Involved in a camphor oxidation system.

    Polypeptides: Camphor 5-monooxygenaseFunction: camphor 5-monooxygenase activity
  2. Drug

    Panitumumab

    go.drugbank.com/drugs/DB01269
    ApprovedInvestigational

    Panitumumab (ABX-EGF) is a recombinant human IgG2 monoclonal antibody that binds specifically to the human epidermal growth factor receptor (EGFR). This drug is an antineoplastic agent. … Panitumumab was granted FDA approval on 27 September 2006.[L17663]

    Products: VECTIBIX 20 MG/ML 5 ML IV INFUZYON ICIN COZELTI ICEREN FLAKON, 1 ADET, VECTIBIX® 20 MG/ ML
  3. Drug

    Sibutramine

    go.drugbank.com/drugs/DB01105
    ApprovedIllicitWithdrawn

    It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled substance in the United States. … In October 2010, Sibutramine was withdrawn from Canadian and U.S. markets due to concerns that the drug increases the risk of heart attack and stroke in patients with a history of heart disease.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: OBESTOPPOR 5 MG CAPSULAS, SINHABIT 15 MG
  4. Drug

    Zuclopenthixol

    go.drugbank.com/drugs/DB01624
    ApprovedInvestigational

    Known drug targets of zuclopenthixol include 5-hydroxytryptamine receptor 2A, D(1B) dopamine receptor, D(2) dopamine receptor, D(1A) dopamine receptor, and alpha-1A adrenergic receptor. … These are organic polycyclic compounds containing a thioxanthene moiety, which is an aromatic tricycle derived from xanthene by replacing the oxygen atom with a sulfur atom.

    Synonyms: (Z)-4-(3-(2-Chlorothioxanthen-9-ylidene)propyl)-1-piperazineethanolInternational brands: Ciatyl-Z
  5. Drug

    Methotrimeprazine

    go.drugbank.com/drugs/DB01403
    Approved

    (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) … A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine.

    Synonyms: (-)-(2R)-3-(2-methoxy-10H-phenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine, (-)-10-(3-(Dimethylamino)-2-methylpropyl)-2-methoxyphenothiazineCategories: Serotonin 5-HT2 Receptor Antagonists, Serotonin 5-HT2A Receptor Antagonists
  6. Drug

    Trastuzumab

    go.drugbank.com/drugs/DB00072
    ApprovedInvestigational

    Produced in CHO cell cultures, trastuzumab is a recombinant IgG1 kappa, humanized monoclonal antibody [A40276] that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular … -2 protein in tumours.

    Mixtures: PHESGO® 1200 MG/600 MG, PHESGO® 1200 MG/600 MGCategories: HER2 (Human Epidermal Growth Factor Receptor 2) inhibitors
  7. Drug

    Amsacrine

    go.drugbank.com/drugs/DB00276
    ApprovedInvestigationalWithdrawn

    Aminoacridine derivative that is a potent intercalating antineoplastic agent. … It is effective in the treatment of acute leukemias and malignant lymphomas, but has poor activity in the treatment of solid tumors.

    Synonyms: m-AMSA, 4'-(9-Acridinylamino)methanesulfon-m-anisidideInternational brands: AMSA P-D
  8. Drug

    Ivermectin

    go.drugbank.com/drugs/DB00602
    ApprovedInvestigationalVet approved

    [L31453] Ivermectin itself is a mixture of two avermectins, comprising roughly 90% 5-O-demethyl-22,23-dihydroavermectin A<sub>1a</sub> (22,23-dihydroavermectin B<sub>1a</sub>) and 10% 5-O-demethyl-25-de … Due to a number of factors - for example, the relatively low number of patients per trial and the speed at which these trials were conducted - studies on the use of ivermectin in COVID-19 have been fraught

    Mixtures: Heartgard Plus Chewable Tablet for Dogs - 26 - 50 lbs, Heartgard Plus Chewable Tablet for Dogs - 51 - 100 lbsCategories: Compounds used in a research, industrial, or household setting, P-glycoprotein inducers
  9. Drug

    Methylene blue

    go.drugbank.com/drugs/DB09241
    ApprovedInvestigational

    clinical trials to be an inhibitor of Tau protein aggregation. … Its use as an urinary tract antiseptic has also been investigated.

    Synonyms: Basic Blue 9, C.I. basic blue 9Mixtures: UR N-C Urinary Antiseptic, Me NaPhos MB Hyo 1
  10. Drug

    Gadoversetamide

    go.drugbank.com/drugs/DB00538
    Approved

    Gadoversetamide, marketed under the trade name OptiMARK, is a gadolinium compound used as a contrast agent in magnetic resonance imaging (MRI), particularly imaging of the brain, spine and liver.

    Categories: Compounds used in a research, industrial, or household settingProducts: OPTIMARK 500 MIKROMOL/ML IV. ENJ. ICIN COZ. ICEREN FLAKON, 15 ML, OPTIMARK 500 MIKROMOL/ML IV. ENJ. ICIN COZELTI ICEREN KUL.HAZIR SIRINGA, 15 ML