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Displaying results 2641 - 2650 of 10000 in total
  1. Drug

    Smallpox (Vaccinia) Vaccine, Live

    go.drugbank.com/drugs/DB14711
    ApprovedInvestigational

    [L12747] ACAM2000, a percutaneously administered smallpox vaccine that was approved by the FDA in 2007, contains live antigens of this strain. … [L12747] In August 2024, ACAM2000 was additionally approved for the prevention of mpox infection in high-risk individuals.[L51499]

    Categories: Complex Mixtures
  2. Drug

    Berdazimer

    go.drugbank.com/drugs/DB18712
    Approved

    Berdazimer is a polymeric substance consisting of a polysiloxane backbone (Si-O-Si bonds) with covalently bound N-diazeniumdiolate nitric oxide (NO) donors. … It is one of the 5 most prevalent skin diseases in the world and the third-most common viral skin infection in children.

    Synonyms: Silsesquioxanes, 3-(2-hydroxy-1-methyl-2-nitrosohydrazinyl)propyl 3-(methylamino)propyl, polymers with silicic acid (h4sio4) tetra-et ester, hydroxy-terminated
  3. Drug

    Ephedra sinica root

    go.drugbank.com/drugs/DB01363
    ApprovedNutraceutical

    The sale of ephedra-containing supplements intended to increase muscle weight or promote weight loss was banned in the United States in 2004 due to the risk for adverse effects and a lack of evidence for … The drug is still sold in Canada in OTC formulations for respiratory conditions associated with bronchial asthma.

    Categories: Complex MixturesSynonyms: Ma huang gen (ephedra sinica), Cao ma huang root
  4. Drug

    Alatrofloxacin

    go.drugbank.com/drugs/DB09335
    ApprovedWithdrawn

    It was withdrawn from the U.S. market in 2001.

  5. Target

    Integrase, catalytic core

    go.drugbank.com/bio_entities/BE0003386
    TargetNitrosomonas europaea (strain ATCC 19718 / NBRC 14298)

    Polypeptides: Integrase, catalytic core
  6. Target

    Neurocan core protein

    go.drugbank.com/bio_entities/BE0004512
    TargetHumans

    May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid

    Polypeptides: Neurocan core protein
  7. Target

    Versican core protein

    go.drugbank.com/bio_entities/BE0004606
    TargetHumans

    May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid

    Polypeptides: Versican core proteinSynonyms: Chondroitin sulfate proteoglycan core protein 2
  8. Drug

    Levacetylmethadol

    go.drugbank.com/drugs/DB01227
    ApprovedWithdrawn

    It is used mainly in the treatment of narcotic dependence. Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. … The production of levacetylmethadol in the US has ceased as well.[L44052,T862]

    Categories: Drugs Used in Opioid Dependence, Drugs Used in Addictive Disorders
  9. Drug

    Casirivimab

    go.drugbank.com/drugs/DB15941
    ApprovedInvestigational

    [A221495] On November 21 2020, the FDA authorized emergency approval of REGEN-COV2 to treat mild to moderate COVID-19 in patients aged 12 years and older. … [L23524] In November 2021, the same indication was approved by the EMA.

  10. Drug

    Teclistamab

    go.drugbank.com/drugs/DB16655
    ApprovedInvestigational

    [A253587] On August 24, 2022, the European Commission (EC) granted conditional marketing authorization of teclistamab as first-in-class bispecific antibody for the treatment of multiple myeloma, marking … Teclistamab is an IgG4-PAA bispecific antibody that targets the CD3 receptor expressed on the surface of T cells and B cell maturation antigen (BCMA) expressed on malignant multiple myeloma cells.