Smallpox (Vaccinia) Vaccine, Live

Identification

Brand Names
Acam2000
Generic Name
Smallpox (Vaccinia) Vaccine, Live
DrugBank Accession Number
DB14711
Background

The New York City Board of Health strain of Vaccinia is a viral strain used as a component of some smallpox vaccinations.1 ACAM2000, a percutaneously administered smallpox vaccine that was approved by the FDA in 2007, contains live antigens of this strain.1

Type
Biotech
Groups
Approved
Biologic Classification
Vaccines
Attenuated
Synonyms
  • Smallpox (vaccinia) vaccine, live
  • Smallpox vaccine
  • Vaccinia virus live antigen, B
  • Vaccinia virus strain new york city board of health live (attenuated) antigen
  • Vaccinia virus strain new york city board of health live antigen
  • Vaccininum
  • Vaccinotoxinum

Pharmacology

Indication

The live antigen of the New York City Board of Health strain of Vaccinia is indicated (within the ACAM2000 formulation) for active immunization against smallpox disease in patients determined to be at high risk of contracting smallpox infection.1

Pharmacology
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Associated Conditions
Contraindications & Blackbox Warnings
Contraindications
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbataceptThe therapeutic efficacy of Smallpox (Vaccinia) Vaccine, Live can be decreased when used in combination with Abatacept.
AdalimumabThe therapeutic efficacy of Smallpox (Vaccinia) Vaccine, Live can be decreased when used in combination with Adalimumab.
AldesleukinThe therapeutic efficacy of Smallpox (Vaccinia) Vaccine, Live can be decreased when used in combination with Aldesleukin.
AlefaceptThe therapeutic efficacy of Smallpox (Vaccinia) Vaccine, Live can be decreased when used in combination with Alefacept.
AlemtuzumabThe therapeutic efficacy of Smallpox (Vaccinia) Vaccine, Live can be decreased when used in combination with Alemtuzumab.
AltretamineThe therapeutic efficacy of Smallpox (Vaccinia) Vaccine, Live can be decreased when used in combination with Altretamine.
AmsacrineThe therapeutic efficacy of Smallpox (Vaccinia) Vaccine, Live can be decreased when used in combination with Amsacrine.
AnakinraThe therapeutic efficacy of Smallpox (Vaccinia) Vaccine, Live can be decreased when used in combination with Anakinra.
Antilymphocyte immunoglobulin (horse)The therapeutic efficacy of Smallpox (Vaccinia) Vaccine, Live can be decreased when used in combination with Antilymphocyte immunoglobulin (horse).
Antithymocyte immunoglobulin (rabbit)The therapeutic efficacy of Smallpox (Vaccinia) Vaccine, Live can be decreased when used in combination with Antithymocyte immunoglobulin (rabbit).
Interactions
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Food Interactions
No interactions found.

Products

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Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Acam2000Injection, powder, lyophilized, for solution100000000 [PFU]/1mLPercutaneousEmergent Product Development Gaithersburg Inc.2007-08-31Not applicableUS flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
4SV59689SK
CAS number
Not Available

References

General References
  1. FDA Approved Drug Products: ACAM2000 (Smallpox (Vaccinia) Vaccine, Live) for percutaneous administration [Link]
RxNav
1492300

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4RecruitingBasic ScienceSmallpox Vaccine Adverse Reaction1
3CompletedOtherSmallpox Vaccine Adverse Reaction1
3CompletedPrevention18-42 Year Old Healthy Vaccinia-naïve Subjects1
3CompletedPreventionSmallpox2
2CompletedPreventionPoxvirus Infection / Smallpox1
2CompletedPreventionSmallpox7
2TerminatedPreventionSmallpox1
2, 3CompletedPreventionSmallpox1
1CompletedPreventionHuman Immunodeficiency Virus (HIV) Infections2
1CompletedPreventionSmallpox4

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Injection, powder, lyophilized, for solutionPercutaneous100000000 [PFU]/1mL
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available

Drug created on October 02, 2018 14:34 / Updated on October 04, 2020 11:46