Identification
- Brand Names
- Acam2000
- Generic Name
- Smallpox (Vaccinia) Vaccine, Live
- DrugBank Accession Number
- DB14711
- Background
The New York City Board of Health strain of Vaccinia is a viral strain used as a component of some smallpox vaccinations.1 ACAM2000, a percutaneously administered smallpox vaccine that was approved by the FDA in 2007, contains live antigens of this strain.1
- Type
- Biotech
- Groups
- Approved
- Biologic Classification
- Vaccines
Attenuated - Synonyms
- Smallpox (vaccinia) vaccine, live
- Smallpox vaccine
- Vaccinia virus live antigen, B
- Vaccinia virus strain new york city board of health live (attenuated) antigen
- Vaccinia virus strain new york city board of health live antigen
- Vaccininum
- Vaccinotoxinum
Pharmacology
- Indication
The live antigen of the New York City Board of Health strain of Vaccinia is indicated (within the ACAM2000 formulation) for active immunization against smallpox disease in patients determined to be at high risk of contracting smallpox infection.1
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- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbatacept The therapeutic efficacy of Smallpox (Vaccinia) Vaccine, Live can be decreased when used in combination with Abatacept. Adalimumab The therapeutic efficacy of Smallpox (Vaccinia) Vaccine, Live can be decreased when used in combination with Adalimumab. Aldesleukin The therapeutic efficacy of Smallpox (Vaccinia) Vaccine, Live can be decreased when used in combination with Aldesleukin. Alefacept The therapeutic efficacy of Smallpox (Vaccinia) Vaccine, Live can be decreased when used in combination with Alefacept. Alemtuzumab The therapeutic efficacy of Smallpox (Vaccinia) Vaccine, Live can be decreased when used in combination with Alemtuzumab. Altretamine The therapeutic efficacy of Smallpox (Vaccinia) Vaccine, Live can be decreased when used in combination with Altretamine. Amsacrine The therapeutic efficacy of Smallpox (Vaccinia) Vaccine, Live can be decreased when used in combination with Amsacrine. Anakinra The therapeutic efficacy of Smallpox (Vaccinia) Vaccine, Live can be decreased when used in combination with Anakinra. Anifrolumab The therapeutic efficacy of Smallpox (Vaccinia) Vaccine, Live can be decreased when used in combination with Anifrolumab. Antilymphocyte immunoglobulin (horse) The therapeutic efficacy of Smallpox (Vaccinia) Vaccine, Live can be decreased when used in combination with Antilymphocyte immunoglobulin (horse). 
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- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Acam2000 Injection, powder, lyophilized, for solution 100000000 [PFU]/1mL Percutaneous Emergent Product Development Gaithersburg Inc. 2007-08-31 Not applicable US 
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 4SV59689SK
- CAS number
- Not Available
References
- General References
- FDA Approved Drug Products: ACAM2000 (Smallpox (Vaccinia) Vaccine, Live) for percutaneous administration [Link]
- External Links
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Basic Science Smallpox Vaccine Adverse Reaction 1 3 Completed Other Smallpox Vaccine Adverse Reaction 1 3 Completed Prevention 18-42 Year Old Healthy Vaccinia-naïve Subjects 1 3 Completed Prevention Variola Major (Smallpox) 2 2 Completed Prevention Poxvirus Infection / Variola Major (Smallpox) 1 2 Completed Prevention Variola Major (Smallpox) 7 2 Terminated Prevention Variola Major (Smallpox) 1 2, 3 Completed Prevention Variola Major (Smallpox) 1 1 Completed Prevention Human Immunodeficiency Virus (HIV) Infections 2 1 Completed Prevention Variola Major (Smallpox) 4
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Injection, powder, lyophilized, for solution Percutaneous 100000000 [PFU]/1mL Injection, powder, lyophilized, for solution Percutaneous 750000 PFU - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
Drug created at October 02, 2018 14:34 / Updated at October 04, 2020 11:46