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Olaparib
go.drugbank.com/drugs/DB09074ApprovedInvestigational[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell … Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexZolazepam
go.drugbank.com/drugs/DB11555ExperimentalVet approvedIt is around four times the potency of diazepam but it is both water-soluble and un-ionized at physiological pH meaning that its onset is very fast. … Zolazepam is a pyrazolodiazepinone derivative used as an anaesthetic in veterinary medicine.
Synthetic Conjugated Estrogens, B
go.drugbank.com/drugs/DB09318ApprovedConjugated Equine Estrogens (CEEs) are derived from the urine of pregnant mares and contain a blend of at least 10 estrogen derivatives. … There is currently no generic form of CEEs available as a detailed analytical characterization of the active ingredients or of their estrogenic activity is not available at this time.
Nafcillin
go.drugbank.com/drugs/DB00607ApprovedInvestigationalIt may be used as a first-line therapy in Methicillin-Sensitive *Staphylococcus aureus* infections [A20360]. … A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug.
Emtricitabine
go.drugbank.com/drugs/DB00879ApprovedInvestigational[L9010] Emtricitabine is a cytidine analogue.[L9019] The drug works by inhibiting HIV reverse transcriptase, preventing transcription of HIV RNA to DNA. … Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) indicated for the treatment of HIV infection in adults[L9019] or combined with [tenofovir alafenamide] for the prevention of HIV-1 infection
Mixtures: Ag-emtricitabine / Tenofovir Disoproxil FumarateMercaptopurine
go.drugbank.com/drugs/DB01033ApprovedInvestigationalAn antimetabolite antineoplastic agent with immunosuppressant properties. … It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
Categories: OAT3/SLC22A8 Substrates with a Narrow Therapeutic IndexAbametapir
go.drugbank.com/drugs/DB11932Approveda potential therapeutic target. … [A216183] Topical pediculicides generally lack adequate ovicidal activity,[A216183] including standard-of-care treatments such as [permethrin], and many require a second administration 7-10 days following
Sulfadimethoxine
go.drugbank.com/drugs/DB06150ApprovedVet approvedWithdrawnIt is widely available in Russia as an over-the-counter drug manufactured by a number of Russian pharmaceutical companies. … It is most frequently used in veterinary medicine, although it is approved in some countries for use in humans.
Laronidase
go.drugbank.com/drugs/DB00090ApprovedInvestigationalThe predicted amino acid sequence of the recombinant form, as well as the nucleotide sequence that encodes it, are identical to a polymorphic form of human a-L-iduronidase. … Laronidase is a glycoprotein with a molecular weight of approximately 83 kD.
Pexidartinib
go.drugbank.com/drugs/DB12978ApprovedInvestigational[A182243] Pexidartinib is available in oral formulations and it is commonly marketed as Turalio.[L7901] … [A182240,L7901] Debilitating symptoms often follow with tenosynovial giant cell tumors, along with a risk of significant functional limitations and a reduced quality of life in patients.
Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index